Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe. (Articolo in rivista)

Type
Label
  • Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe. (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1371/journal.pgen.1004353 (literal)
Alternative label
  • Sikora, Martin; Carpenter, Meredith L; Moreno-Estrada, Andres; Henn, Brenna M; Underhill, Peter A; Sanchez-Quinto, Federico; Zara, Ilenia; Pitzalis, Maristella; Sidore, Carlo; Busonero, Fabio; Maschio, Andrea; Angius, Andrea; Jones, Chris; Mendoza-Revilla, Javier; Nekhrizov, Georgi; Dimitrova, Diana; Theodossiev, Nikola; Harkins, Timothy T; Keller, Andreas; Maixner, Frank; Zink, Albert; Abecasis, Goncalo; Sanna, Serena; Cucca, Francesco; Bustamante, Carlos D (2014)
    Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe.
    in PLOS genetics (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Sikora, Martin; Carpenter, Meredith L; Moreno-Estrada, Andres; Henn, Brenna M; Underhill, Peter A; Sanchez-Quinto, Federico; Zara, Ilenia; Pitzalis, Maristella; Sidore, Carlo; Busonero, Fabio; Maschio, Andrea; Angius, Andrea; Jones, Chris; Mendoza-Revilla, Javier; Nekhrizov, Georgi; Dimitrova, Diana; Theodossiev, Nikola; Harkins, Timothy T; Keller, Andreas; Maixner, Frank; Zink, Albert; Abecasis, Goncalo; Sanna, Serena; Cucca, Francesco; Bustamante, Carlos D (literal)
Pagina inizio
  • e1004353 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 10 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 5 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • 1Department of Genetics, Stanford University, Stanford, California, United States of America. 2Institute of Evolutionary Biology (CSIC-UPF), PRBB, Barcelona, Spain. 3CRS4 (Centre for Advanced Studies, Research and Development in Sardinia), Pula, Italy. 4Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Monserrato, Italy. 5Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Monserrato, Italy; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America; Università degli Studi di Sassari, Dip. Scienze Biomediche, Sassari, Italy. 6Istituto di Ricerca Genetica e Biomedica (IRGB), CNR, Monserrato, Italy; Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America. 7Laboratorios de Investigación y Desarrollo, Facultad de Ciencias y Filosofía, Universidad Peruana Cayetano Heredia, Lima, Peru. 8National Archaeological Institute with Museum, Sofia, Bulgaria. 9Sofia University St. Kliment Ohridski, Sofia, Bulgaria. 10Life Technologies, Beverly, Massachusetts, United States of America. 11University Hospital, Saarland University, Saarbrücken, Germany. 12EURAC, Institute for mummies and the Iceman, Bolzano, Italy. 13Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, United States of America. (literal)
Titolo
  • Population genomic analysis of ancient and modern genomes yields new insights into the genetic ancestry of the Tyrolean Iceman and the genetic structure of Europe. (literal)
Abstract
  • Genome sequencing of the 5,300-year-old mummy of the Tyrolean Iceman, found in 1991 on a glacier near the border of Italy and Austria, has yielded new insights into his origin and relationship to modern European populations. A key finding of that study was an apparent recent common ancestry with individuals from Sardinia, based largely on the Y chromosome haplogroup and common autosomal SNP variation. Here, we compiled and analyzed genomic datasets from both modern and ancient Europeans, including genome sequence data from over 400 Sardinians and two ancient Thracians from Bulgaria, to investigate this result in greater detail and determine its implications for the genetic structure of Neolithic Europe. Using whole-genome sequencing data, we confirm that the Iceman is, indeed, most closely related to Sardinians. Furthermore, we show that this relationship extends to other individuals from cultural contexts associated with the spread of agriculture during the Neolithic transition, in contrast to individuals from a hunter-gatherer context. We hypothesize that this genetic affinity of ancient samples from different parts of Europe with Sardinians represents a common genetic component that was geographically widespread across Europe during the Neolithic, likely related to migrations and population expansions associated with the spread of agriculture. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it