http://www.cnr.it/ontology/cnr/individuo/prodotto/ID292790

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. (Articolo in rivista)

Type

Articolo in rivista (Classe)
Prodotto della ricerca (Classe)

Label

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1002/ana.24235 (literal)

Alternative label

Federica Agosta MD, PhD1, Dacia Dalla Libera MD1, Edoardo Gioele Spinelli MD1, Annamaria Finardi BSci1, Elisa Canu PhD1, Alessandra Bergami MLT1, Luisella Bocchio Chiavetto PhD2, Manuela Baronio MD3, Giancarlo Comi MD1,4, Gianvito Martino MD1, Michela Matteoli PhD5,6, Giuseppe Magnani MD1, Claudia Verderio PhD5,6 andRoberto Furlan MD, PhD1,* (2014)
Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease.
in Annals of neurology (Online); John Wiley & Sons Inc., New York (Stati Uniti d'America)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Federica Agosta MD, PhD1, Dacia Dalla Libera MD1, Edoardo Gioele Spinelli MD1, Annamaria Finardi BSci1, Elisa Canu PhD1, Alessandra Bergami MLT1, Luisella Bocchio Chiavetto PhD2, Manuela Baronio MD3, Giancarlo Comi MD1,4, Gianvito Martino MD1, Michela Matteoli PhD5,6, Giuseppe Magnani MD1, Claudia Verderio PhD5,6 andRoberto Furlan MD, PhD1,* (literal)

Pagina inizio

813 (literal)

Pagina fine

25 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

76 (literal)

Rivista

Annals of neurology (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

6 (literal)

Note

ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

1Division of Neuroscience, Institute of Experimental Neurology, Scientific Institute San Raffaele, Milan 2Neuropsychopharmacology Unit, IRCCS Centro S. Giovanni di Dio, Fatebenefratelli, Brescia 3Poliambulanza Foundation, Brescia 4Vita-Salute San Raffaele University, Milan 5CNR Institute of Neuroscience and Department of Medical Pharmacology, Milan 6Istituto Clinico Humanitas IRCCS, Milan, Italy (literal)

Titolo

Myeloid microvesicles in cerebrospinal fluid are associated with myelin damage and neuronal loss in mild cognitive impairment and Alzheimer disease. (literal)

Abstract

OBJECTIVES: We have described cerebrospinal fluid (CSF) myeloid microvesicles (MVs) as a marker of microglia activation during neuroinflammation in Alzheimer disease (AD), and characterized their ability to produce toxic amyloid ?1-42 (A?1-42 ) oligomers from aggregated or soluble substrate. The aim of this study is to investigate the association of CSF myeloid MVs with neuroimaging, clinical, and paraclinical data in AD and mild cognitive impairment (MCI). METHODS: We collected CSF from 106 AD patients, 51 MCI patients, and 29 neurologically healthy controls. We examined CSF myeloid MV content and AD markers. A subgroup of 34 AD and 21 MCI patients underwent structural and diffusion tensor MRI. RESULTS: Higher levels of myeloid MVs were found in the CSF of AD patients and MCI patients converting within 3 years relative to controls, but also, at a lower level, in MCI patients not converting to AD. CSF myeloid MVs were associated with Tau but not with A?1-42 CSF levels. CSF MVs levels correlated with white matter (WM) tract damage in MCI, and with hippocampal atrophy in AD. INTERPRETATION: Microglial MVs are neurotoxic and myelinotoxic in the presence of A?1-42 . CSF myeloid MVs, mirroring microglia activation and MV release, are associated with WM damage in MCI and hippocampal atrophy in AD. This suggests that hippocampal microglia activation, in the presence of A?1-42 in excess, produces neurotoxic and oligodendrotoxic oligomers that, through WM tract damage, spread disease to neighboring and connected areas, causing local microglia activation and propagation of disease through the same sequence of events. Ann Neurol 2014;76:813-825. (literal)

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