Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.toxlet.2013.03.017 (literal)

Alternative label

• Pedata P.; Bergamasco N.; D'Anna A.; Minutolo P.; Servillo L.; Sannolo N.; Balestrieri M.L. (2013)
  Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells
  in Toxicology letters; Elsevier, Amsterdam (Paesi Bassi)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Pedata P.; Bergamasco N.; D'Anna A.; Minutolo P.; Servillo L.; Sannolo N.; Balestrieri M.L. (literal)

Pagina inizio

• 307 (literal)

Pagina fine

• 314 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84877332243&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 219 (literal)

Rivista

• Toxicology letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 3 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Experimental Medicine, Section of Hygiene Occupational Medicine and Forensic Medicine - School of Medicine, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy; Department of Chemical Material and Industrial Production Engineering, University of Naples Federico II, P. Tecchio 80, 80125 Naples, Italy; Institute for Research on Combustion, CNR Naples, P. Tecchio 80, 80125 Naples, Italy; Department of Biochemistry Biophysics and General Pathology, Second University of Naples, Via L. De Crecchio 7, 80138 Naples, Italy (literal)

Titolo

• Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells (literal)

Abstract

• Air pollution exposure in industrialized cities is associated with an increased risk of morbidity and mortality attributed to cardiovascular diseases. Combustion exhausts emitted from motor vehicles and industries represent a major source of nanoparticles in the atmosphere. Flame-generated organic carbon nanoparticles (OC NPs) provide interesting model nanoparticles that simulate fresh combustion emissions near roadways or combustion sources. These model nanoparticles can be produced by controlling flame operating conditions and used to test possible toxicological mechanisms responsible for the observed health effects. OC NPs were used to investigate their possible effect on endothelial cells (EC) growth and production of proinflammatory lipid mediators. Results indicated a dose and time-dependent reduction in cell viability following incubation of EC with OC NPs for 24 and 48. h. Fluorescence-activated cell sorting revealed that EC treated with OC NPs showed a cell proliferation index significantly lower than that of control cells and an increased apoptotic cell death. The annexin assay confirmed the increased apoptotic cell death. Moreover, OC NPs also induced a time-dependent increase of proinflammatory lysophospholipid production. These results, establishing that OC NPs induce EC proinflammatory lysophosholipid production and apoptotic cell death, provide the first evidence of the detrimental effect of OC NPs on EC. © 2013 Elsevier Ireland Ltd. (literal)

Editore

• Elsevier (Editore)

Prodotto di

• Studio dei meccanismi di formazione e sviluppo di diagnostiche avanzate di inquinanti da processi di combustione (ET.P01.004.001) (Modulo)
• Istituto di ricerche sulla combustione (IRC) (Istituto)

Autore CNR

• PATRIZIA MINUTOLO (Persona)

Insieme di parole chiave

• Parole chiave di "Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di ricerche sulla combustione (IRC) (Istituto)
• Studio dei meccanismi di formazione e sviluppo di diagnostiche avanzate di inquinanti da processi di combustione (ET.P01.004.001) (Modulo)

Autore CNR di

• PATRIZIA MINUTOLO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Toxicology letters (Rivista)

Editore di

• Elsevier (Editore)

Insieme di parole chiave di

• Parole chiave di "Apoptotic and proinflammatory effect of combustion-generated organic nanoparticles in endothelial cells" (Insieme di parole chiave)