Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line. (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line. (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.toxlet.2014.09.021 (literal)

Alternative label

• Monaci L., Garbetta A., De Angelis E., Visconti A., Minervini F (2015)
  Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line.
  in Toxicology letters
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Monaci L., Garbetta A., De Angelis E., Visconti A., Minervini F (literal)

Pagina inizio

• 106 (literal)

Pagina fine

• 112 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/25271005 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 232 (literal)

Rivista

• Toxicology letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ISPA-CNR (literal)

Titolo

• Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line. (literal)

Abstract

• Ingestion of food is considered a major route of exposure to many contaminants including mycotoxins. The amount of mycotoxin resisting to the digestion process and potentially absorbable by the systemic circulation is only a smaller part of that ingested. In vitro digestion models turn useful for evaluating mycotoxins bioaccessibility during the intestinal transit and can be intended as a valuable tool for the assessment of mycotoxin bioavailability in food. In this paper we describe a study aimed at investigating toxicity of in vitro gastro-duodenal digests of mycotoxin contaminated bread collected along the digestion time-course. Toxicity tests were carried out on a sensitive RPMI lymphoid B cell line chosen as the most suitable lineage to assess toxicity retained by gastro-duodenal digests. In parallel, a chemical quantification of T-2 and HT-2 toxins contaminating the bread digests was accomplished during the gastric and duodenal transit. The digestive fluids undergoing chemical and toxicological analysis were collected at the beginning and end of gastric phase, and after completion of the duodenal phase. Results proved that a correlation between HT-2 content and toxicity did exist although a more persistent toxic activity was displayed in the later stage of the duodenal phase. This persistent toxicity might be explained by the co-occurrence of unknown HT-2-related conjugates or metabolites formed during digestion. (literal)

Prodotto di

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Metodi innovativi per l'analisi e la riduzione di micotossine, funghi tossigeni ed allergeni nei prodotti agroalimentari (AG.P05.008.002) (Modulo)

Autore CNR

• ANGELO VISCONTI (Unità di personale interno)
• ELISABETTA DE ANGELIS (Persona)
• Antonella Garbetta (Persona)
• LINDA MONACI (Unità di personale interno)
• FIORENZA MINERVINI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line." (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ANGELO VISCONTI (Unità di personale interno)
• FIORENZA MINERVINI (Unità di personale interno)
• ELISABETTA DE ANGELIS (Persona)
• Antonella Garbetta (Persona)
• LINDA MONACI (Unità di personale interno)

Prodotto

• Istituto di scienze delle produzioni alimentari (ISPA) (Istituto)
• Metodi innovativi per l'analisi e la riduzione di micotossine, funghi tossigeni ed allergeni nei prodotti agroalimentari (AG.P05.008.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Toxicology letters (Rivista)

Insieme di parole chiave di

• Keywords of "Assessment of toxic potential of mycotoxin contaminated bread during in vitro human digestion on human B lymphoid cell line." (Insieme di parole chiave)