http://www.cnr.it/ontology/cnr/individuo/prodotto/ID291403
Thiol-ene Mediated Neoglycosylation of Collagen Patches: A Preliminary Study (Articolo in rivista)
- Type
- Label
- Thiol-ene Mediated Neoglycosylation of Collagen Patches: A Preliminary Study (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1021/la404310p (literal)
- Alternative label
Russo, Laura; Battocchio, Chiara; Secchi, Valeria; Magnano, Elena; Nappini, Silvia; Taraballi, Francesca; Gabrielli, Luca; Comelli, Francesca; Papagni, Antonio; Costa, Barbara; Polzonetti, Giovanni; Nicotra, Francesco; Natalello, Antonino; Doglia, Silvia M.; Cipolla, Laura (2014)
Thiol-ene Mediated Neoglycosylation of Collagen Patches: A Preliminary Study
in Langmuir
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Russo, Laura; Battocchio, Chiara; Secchi, Valeria; Magnano, Elena; Nappini, Silvia; Taraballi, Francesca; Gabrielli, Luca; Comelli, Francesca; Papagni, Antonio; Costa, Barbara; Polzonetti, Giovanni; Nicotra, Francesco; Natalello, Antonino; Doglia, Silvia M.; Cipolla, Laura (literal)
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- Note
- ISI Web of Science (WOS) (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- University of Milano-Bicocca; Roma Tre University; Roma Tre University; Consiglio Nazionale delle Ricerche (CNR); University of Milano-Bicocca (literal)
- Titolo
- Thiol-ene Mediated Neoglycosylation of Collagen Patches: A Preliminary Study (literal)
- Abstract
- Despite the relevance of carbohydrates as cues in eliciting specific biological responses, the covalent surface modification of collagen-based matrices with small carbohydrate epitopes has been scarcely investigated. We report thereby the development of an efficient procedure for the chemoselective neoglycosylation of collagen matrices (patches) via a thiol-ene approach, between alkene-derived mono-saccharides and the thiol-functionalized material surface. Synchrotron radiation-induced X-ray photoelectron spectroscopy (SR-XPS), Fourier transform-infrared (FT-IR), and enzyme-linked lectin assay (ELLA) confirmed the effectiveness of the collagen neoglycosylation. Preliminary biological evaluation in osteoarthritic models is reported. The proposed methodology can be extended to any thiolated surface for the development of smart biomaterials for innovative approaches in regenerative medicine. (literal)
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- Autore CNR
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