Gold nanoprisms for photothermal cell ablation in vivo (Articolo in rivista)

Type
Label
  • Gold nanoprisms for photothermal cell ablation in vivo (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.2217/NNM.14.100 (literal)
Alternative label
  • Ambrosone, Alfredo; del Pino, Pablo; Marchesano, Valentina; Parak, Wolfgang J.; de la Fuente, Jesus M.; Tortiglione, Claudia (2014)
    Gold nanoprisms for photothermal cell ablation in vivo
    in Nanomedicine (Lond., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ambrosone, Alfredo; del Pino, Pablo; Marchesano, Valentina; Parak, Wolfgang J.; de la Fuente, Jesus M.; Tortiglione, Claudia (literal)
Pagina inizio
  • 1913 (literal)
Pagina fine
  • 1922 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 13 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Consiglio Nazionale delle Ricerche (CNR); University of Zaragoza; Philipps University Marburg (literal)
Titolo
  • Gold nanoprisms for photothermal cell ablation in vivo (literal)
Abstract
  • Aim: To develop new methodologies for selective cell ablation in a temporally and spatially precise fashion in model organisms. Materials & methods: living polyps (Hydra vulgaris) treated with gold nanoprisms were near-infrared (NIR) irradiated and the photothermal effects evaluated at whole-animal, cellular and molecular levels. Results: Nanoprisms showed good efficiency of internalization in living specimens, with no sign of toxicity; under NIR irradiation they induced cell death and the overexpression of the hsp70 gene. Conclusion: gold nanoprisms could be employed as efficient heat mediators in model organisms, and NIR-triggered cell ablation may represent a new advanced tool to study cell function. Solving bioethical and economical issues, invertebrates may provide alternative models bridging the gap between cell research and preclinical studies of photothermal therapy. (literal)
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