Photophysics and ex vivo biodistribution of b-cyclodextrin-meso- tetra(m-hydroxyphenyl)porphyrin conjugate for biomedical applications (Articolo in rivista)

Type
Label
  • Photophysics and ex vivo biodistribution of b-cyclodextrin-meso- tetra(m-hydroxyphenyl)porphyrin conjugate for biomedical applications (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1039/c4pp00088a (literal)
Alternative label
  • Kirejev, Vladimir; Gonçalves, Alexandrino Ricardo S; Aggelidou, Chrysie; Manet, Ilse; Mårtensson, Jerker; Yannakopoulou, Konstantina; Ericson, Marica B. (2014)
    Photophysics and ex vivo biodistribution of b-cyclodextrin-meso- tetra(m-hydroxyphenyl)porphyrin conjugate for biomedical applications
    in Photochemical & photobiological sciences (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Kirejev, Vladimir; Gonçalves, Alexandrino Ricardo S; Aggelidou, Chrysie; Manet, Ilse; Mårtensson, Jerker; Yannakopoulou, Konstantina; Ericson, Marica B. (literal)
Pagina inizio
  • 1185 (literal)
Pagina fine
  • 1191 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/record/display.url?eid=2-s2.0-84904438422&origin=inward (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 13 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 8 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Goteborgs Universitet; Demokritos National Centre for Scientific Research; Istituto Per La Sintesi Organica E La Fotoreattivita, Bologna; Chalmers Tekniska Hogskola (literal)
Titolo
  • Photophysics and ex vivo biodistribution of b-cyclodextrin-meso- tetra(m-hydroxyphenyl)porphyrin conjugate for biomedical applications (literal)
Abstract
  • Low aqueous solubility of porphyrin-based photosensitizers hampers their clinical use in photodynamic therapy because of complex delivery. In this study, we explore meso-tetra(m-hydroxyphenyl)-21,23H-porphyrin (mTHPP), a potent photosensitizer, covalently attached to ?-cyclodextrin (CD-mTHPP) with a focus on topical delivery and cellular uptake. The photophysical properties of CD-mTHPP were examined using steady-state fluorescence and lifetime measurements verifying increased aqueous solubility. Confocal and fluorescence lifetime imaging microscopy on human squamous carcinoma cells (A431) evidenced a cytoplasmic uptake of CD-mTHPP in predominantly monomeric form. CD-mTHPP was also delivered to human skin ex vivo and the skin penetration was assessed using two-photon fluorescence microscopy. The results indicated that CD-mTHPP exhibits improved skin distribution compared to mTHPP alone using aqueous vehicles. Thus the CD-mTHPP conjugate demonstrates improved biodistribution ex vivo compared to mTHPP and is a promising multimodal system for photodynamic therapy. This journal is © the Partner Organisations 2014. (literal)
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