Host-guest interactions in Fe(III)-trimesate MOF nanoparticles loaded with doxorubicin (Articolo in rivista)

Type
Label
  • Host-guest interactions in Fe(III)-trimesate MOF nanoparticles loaded with doxorubicin (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/jp503809w (literal)
Alternative label
  • Anand R.; Borghi F.; Manoli F.; Manet I.; Agostoni V.; Reschiglian P.; Gref R.; Monti S. (2014)
    Host-guest interactions in Fe(III)-trimesate MOF nanoparticles loaded with doxorubicin
    in The journal of physical chemistry. B (1997 : Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Anand R.; Borghi F.; Manoli F.; Manet I.; Agostoni V.; Reschiglian P.; Gref R.; Monti S. (literal)
Pagina inizio
  • 8532 (literal)
Pagina fine
  • 8539 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84905028698&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 118 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 29 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto per la Sintesi Organica e la Fotoreattività, ISOF-CNR, Via Piero Gobetti 101, Bologna I-40129, Italy; Université Paris-Sud, UMR CNRS 8612, 5 rue JB Clément, Châtenay Malabry 92290, France; Dipartimento di Chimica G. Ciamician, Università di Bologna, Via Selmi 2, Bologna I-40126, Italy; ByFlow Srl, Via Piero Gobetti 52/3, Bologna I-40129, Italy (literal)
Titolo
  • Host-guest interactions in Fe(III)-trimesate MOF nanoparticles loaded with doxorubicin (literal)
Abstract
  • Doxorubicin (DOX) entrapment in porous Fe(III)-trimesate metal organic frameworks (MIL-100(Fe)) nanoparticles was investigated in neutral Tris buffer via UV-vis absorption, circular dichroism (CD), and fluorescence. The binding constants and the absolute spectra of the DOX-MIL-100(Fe) complexes were determined via absorption and fluorescence titrations. A binding model where DOX associates as monomer to the dehydrated Fe3O (OH)(H2O)2 [(C6H3)(CO2)3]2 structural unit in 1:1 stoichiometry, with apparent association constant of (1.1 to 1.8) × 104 M-1, was found to reasonably fit the experimental data. Spectroscopic data indicate that DOX binding occurs via the formation of highly stable coordination bonds between one or both deprotonated hydroxyl groups of the aglycone moiety and coordinatively unsaturated Fe(III) centers. Complete quenching of the DOX fluorescence and remarkable thermal and photochemical stability were observed for DOX incorporated in the MIL-100(Fe) framework. (literal)
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