Factors affecting T cell responses induced by fully synthetic glyco-gold-nanoparticles (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Factors affecting T cell responses induced by fully synthetic glyco-gold-nanoparticles (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c2nr32338a (literal)

Alternative label

• Fallarini S.; Paoletti T.; Battaglini C.O.; Ronchi P.; Lay L.; Bonomi R.; Jha S.; Mancin F.; Scrimin P.; Lombardi G. (2013)
  Factors affecting T cell responses induced by fully synthetic glyco-gold-nanoparticles
  in Nanoscale (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Fallarini S.; Paoletti T.; Battaglini C.O.; Ronchi P.; Lay L.; Bonomi R.; Jha S.; Mancin F.; Scrimin P.; Lombardi G. (literal)

Pagina inizio

• 390 (literal)

Pagina fine

• 400 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84870879127&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 5 (literal)

Rivista

• Nanoscale (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Pharmaceutical Sciences, University of Piemonte Orientale Amedeo Avogadro, Via Bovio 6, 28100 Novara, Italy; Department of Organic and Industrial Chemistry, CISI, University of Milano, Via Venezian 21, 20133 Milan, Italy; Department of Chemical Sciences, ITM-CNR, University of Padova, Via Marzolo 1, 35131 Padova, Italy (literal)

Titolo

• Factors affecting T cell responses induced by fully synthetic glyco-gold-nanoparticles (literal)

Abstract

• We have synthesized and characterized nearly monodisperse and highly pure gold nanoparticles (2 and 5 nm) coated with non-immunoactive mono- and disaccharides, modelled after the capsular polysaccharide of serogroup A of the Neisseria meningitidis bacterium. We have used them to test their ability to induce immune cell responses as a consequence of their multivalency. The results indicate that they are indeed immunoactive and that immunoactivity is strongly dependent on size, and larger, 5 nm nanoparticles perform far better than smaller, 2 nm ones. Immune response (activation of macrophages) initiates with the whole nanoparticle recognition by the surface of antigen-presenting cells, independent of the saccharide oligomerization (or charge) on the nanoparticle surface. The induction of T cell proliferation and the increase of IL-2 levels, a consequence of the expression of MHC II involved in antigen presentation, require the presence of a disaccharide on the nanoparticle, not just a monosaccharide. A possible explanation is that, at this stage, the saccharides are detached from the gold surface. These results may provide leads for designing new saccharide-based, nanoparticle-conjugate vaccines. © 2013 The Royal Society of Chemistry. (literal)

Prodotto di

• Institute of molecular science and technologies (ISTM) (Istituto)
• Nanobiotecnologie per lo studio delle interazioni molecolari (PM.P05.013.001) (Modulo)

Autore CNR

• LUIGI LAY (Unità di personale esterno)

Incoming links:

Prodotto

• Institute of molecular science and technologies (ISTM) (Istituto)
• Nanobiotecnologie per lo studio delle interazioni molecolari (PM.P05.013.001) (Modulo)

Autore CNR di

• LUIGI LAY (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nanoscale (Rivista)