Raman Spectroscopy: a Promising Technique for Investigation of trans and cis Cholesteryl Ester isomers in Biological Samples (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Raman Spectroscopy: a Promising Technique for Investigation of trans and cis Cholesteryl Ester isomers in Biological Samples (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Alternative label

• M. Melchiorre, C. Ferreri, A. Tinti, C. Chatgilialoglu, A.Torreggiani (2015)
  Raman Spectroscopy: a Promising Technique for Investigation of trans and cis Cholesteryl Ester isomers in Biological Samples
  in Applied spectroscopy
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• M. Melchiorre, C. Ferreri, A. Tinti, C. Chatgilialoglu, A.Torreggiani (literal)

Rivista

• Applied spectroscopy (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• ISOF CNR Università di Bologna (literal)

Titolo

• Raman Spectroscopy: a Promising Technique for Investigation of trans and cis Cholesteryl Ester isomers in Biological Samples (literal)

Abstract

• Lipid geometry is an important issue in biology and medicine. The cis-trans geometry conversion of double bonds in lipids is an endogenous process that can be mediated by sulfur-centered free radicals. Trans isomers of poly-unsaturated fatty acids can be assumed as marker of free radical stress and their recognition in biological samples can be helped by synthesis and characterization of appropriate reference compounds. Fractions of plasma lipids such as cholesteryl linoleate and arachidonate esters are interesting targets for their connection with membrane phospholipid turnover and their roles in cardiovascular health. In this context Raman spectroscopy can give a useful contribution, since Raman analysis can be performed directly on the lipid extracts without any derivatization reaction, is non-destructive, and can rapidly supply information. This paper is focused on the build-up of Raman spectral libraries of different cis and trans isomers of cholesteryl esters to be used as references for the examination of complex biological samples and facilitate the isomer recognition. Unsaturated cholesteryl esters obtained by chemical synthesis and having differences in the alkyl chain length and/or the double bonds number, were analyzed. The potential of Raman analysis for trans isomer detection in biological samples was successfully tested on some cholesteryl ester lipid fraction from human serum. The data presented here suggest promising applications of Raman spectroscopy in metabolomics and lipidomics. (literal)

Prodotto di

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR

• CARLA FERRERI (Unità di personale interno)
• CHRYSSOSTOMOS CHATGILIALOGLU (Unità di personale interno)
• ARMIDA TORREGGIANI (Unità di personale interno)
• MICHELE MELCHIORRE (Unità di personale esterno)

Insieme di parole chiave

• Parole chiave di "Raman Spectroscopy: a Promising Technique for Investigation of trans and cis Cholesteryl Ester isomers in Biological Samples" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Studio delle interazioni legando-recettore in sistemi modello mediante metodi spettroscopici e fotofisici (LEGARE) (PM.P06.005.002) (Modulo)

Autore CNR di

• CARLA FERRERI (Unità di personale interno)
• CHRYSSOSTOMOS CHATGILIALOGLU (Unità di personale interno)
• ARMIDA TORREGGIANI (Unità di personale interno)
• MICHELE MELCHIORRE (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Applied spectroscopy (Rivista)

Insieme di parole chiave di

• Parole chiave di "Raman Spectroscopy: a Promising Technique for Investigation of trans and cis Cholesteryl Ester isomers in Biological Samples" (Insieme di parole chiave)