Multiscale Patterning of a Biomimetic Scaffold Integrated with Composite Microspheres (Articolo in rivista)

Type
Label
  • Multiscale Patterning of a Biomimetic Scaffold Integrated with Composite Microspheres (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Minardi, Silvia; Sandri, Monica; Martinez, Jonathan O.; Yazdi, Iman K.; Liu, Xeuwu; Ferrari, Mauro; Weiner, Bradley K.; Tampieri, Anna; Tasciotti, Ennio (2014)
    Multiscale Patterning of a Biomimetic Scaffold Integrated with Composite Microspheres
    in Small (Weinh., Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Minardi, Silvia; Sandri, Monica; Martinez, Jonathan O.; Yazdi, Iman K.; Liu, Xeuwu; Ferrari, Mauro; Weiner, Bradley K.; Tampieri, Anna; Tasciotti, Ennio (literal)
Pagina inizio
  • 3943 (literal)
Pagina fine
  • 3953 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 10 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 11 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 19 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Natl Res Council Italy ISTEC CNR; Houston Methodist Res Inst; Univ Texas Hlth Sci Ctr Houston; Univ Houston; Methodist Hosp (literal)
Titolo
  • Multiscale Patterning of a Biomimetic Scaffold Integrated with Composite Microspheres (literal)
Abstract
  • The ideal scaffold for regenerative medicine should concurrently mimic the structure of the original tissue from the nano- up to the macroscale and recapitulate the biochemical composition of the extracellular matrix (ECM) in space and time. In this study, a multiscale approach is followed to selectively integrate different types of nanostructured composite microspheres loaded with reporter proteins, in a multicompartment collagen scaffold. Through the preservation of the structural cues of the functionalized collagen scaffold at the nano- and microscale, its macroscopic features (pore size, porosity, and swelling) are not altered. Additionally, the spatial confinement of the microspheres allows the release of the reporter proteins in each of the layers of the scaffold. Finally, the staged and zero-order release kinetics enables the temporal biochemical patterning of the scaffold. The versatile manufacturing of each component of the scaffold results in the ability to customize it to better mimic the architecture and composition of the tissues and biological systems. (literal)
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