Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.biomaterials.2014.03.069 (literal)

Alternative label

• Alghamdi H.S.; Bosco R.; Both S.K.; Iafisco M.; Leeuwenburgh S.C.G.; Jansen J.A.; Van den Beucken J.J.J.P. (2014)
  Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats
  in Biomaterials
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Alghamdi H.S.; Bosco R.; Both S.K.; Iafisco M.; Leeuwenburgh S.C.G.; Jansen J.A.; Van den Beucken J.J.J.P. (literal)

Pagina inizio

• 5482 (literal)

Pagina fine

• 5490 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84899484537&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 35 (literal)

Rivista

• Biomaterials (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 21 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Biomaterials, Radboud umc, Nijmegen, The Netherlands Department of Periodontics and Community Dentistry, College of Dentistry, King Saud University, Riyadh, Saudi Arabia Institute of Science and Technology for Ceramics (ISTEC), National Research Council (CNR), Via Granarolo 64, 48018 Faenza, Italy (literal)

Titolo

• Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats (literal)

Abstract

• The prevalence of osteoporosis will increase within the next decades due to the aging world population, which can affect the bone healing response to dental and orthopedic implants. Consequently, local drug targeting of peri-implant bone has been proposed as a strategy for the enhancement of bone-implant integration in osteoporotic conditions. In the present study, an established in-vivo femoral condyle implantation model in osteoporotic and healthy bone is used to analyze the osteogenic capacity of titanium implants coated with bisphosphonate (BP)-loaded calcium phosphate nanoparticles (nCaP) under compromised medical conditions. After 4 weeks of implantation, peri-implant bone volume (%BV; by ?CT) and bone area (%BA; by histomorphometry) were significantly increased within a distance of 500?m from implant surfaces functionalized with BP compared to control implants in osteoporotic and healthy conditions. Interestingly, the deposition of nCaP/BP coatings onto implant surfaces increased both peri-implant bone contact (%BIC) and volume (%BV) compared to the deposition of nCaP or BP coatings individually, in osteoporotic and healthy conditions. The results of real-time PCR revealed similar osteogenic gene expression levels to all implant surfaces at 4-weeks post-implantation. In conclusion, simultaneous targeting of bone formation (by nCaP) and bone resorption (by BP) using nCaP/BP surface coatings represents an effective strategy for synergistically improvement of bone-implant integration, especially in osteoporotic conditions. © 2014 Elsevier Ltd. (literal)

Prodotto di

• Processi biomorfici e sviluppo di materiali biomimetici ad elevate performance bio-meccaniche per applicazioni in ingegneria tessutale (ME.P06.018.002) (Modulo)
• Institute of science and technology for ceramics (ISTEC) (Istituto)

Autore CNR

• MICHELE IAFISCO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of science and technology for ceramics (ISTEC) (Istituto)
• Processi biomorfici e sviluppo di materiali biomimetici ad elevate performance bio-meccaniche per applicazioni in ingegneria tessutale (ME.P06.018.002) (Modulo)

Autore CNR di

• MICHELE IAFISCO (Unità di personale interno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Biomaterials (Rivista)

Insieme di parole chiave di

• Keywords of "Synergistic effects of bisphosphonate and calcium phosphate nanoparticles on peri-implant bone responses in osteoporotic rats" (Insieme di parole chiave)