http://www.cnr.it/ontology/cnr/individuo/prodotto/ID289560
The MAP(K) of fear: From memory consolidation to memory extinction (Articolo in rivista)
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- Label
- The MAP(K) of fear: From memory consolidation to memory extinction (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.brainresbull.2013.09.007 (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Cestari V.1; Rossi-Arnaud C.2; Saraulli D.3; Costanzi M.4 (literal)
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-84901486986&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- 1 Institute of Cellular Biology and Neurobiology, National Research Council and Fondazione Santa Lucia, via del Fosso di Fiorano 64, 00143 Rome, Italy; Department of Psychology and \"Daniel Bovet\" Center, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy.
2 Department of Psychology, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy.
3 Institute of Cellular Biology and Neurobiology, National Research Council and Fondazione Santa Lucia, via del Fosso di Fiorano 64, 00143 Rome, Italy; Department of Psychology, Sapienza University of Rome, via dei Marsi 78, 00185 Rome, Italy.
4 Institute of Cellular Biology and Neurobiology, National Research Council and Fondazione Santa Lucia, via del Fosso di Fiorano 64, 00143 Rome, Italy; Department of Human Sciences, LUMSA University, p.zza delle Vaschette 101, 00193 Rome, Italy. (literal)
- Titolo
- The MAP(K) of fear: From memory consolidation to memory extinction (literal)
- Abstract
- The highly conserved mitogen-activated protein kinase/extracellular signal-regulated kinase (MAPK/ERK) signaling cascade is involved in several intracellular processes ranging from cell differentiation to proliferation, as well as in synaptic plasticity. In the last two decades, the role of MAPK/ERK in long-term memory formation in mammals, particularly in fear-related memories, has been extensively investigated.In this review we describe knowledge advancement on the role of MAPK/ERK in orchestrating the intracellular processes that lead to the consolidation, reconsolidation and extinction of fear memories. In doing so, we report studies in which the specific role of MAP/ERK in switching from memory formation to memory erasure has been suggested. The possibility to target MAPK/ERK in developing and/or refining pharmacological approaches to treat psychiatric disorders in which fear regulation is defective has also been envisaged. © 2013 Elsevier Inc. (literal)
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