Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/pr500806k | J (literal)

Alternative label

• I. Inserra, F. Iavarone, C. Martelli, L. D'Angelo, D. Delfino, D.V. Rossetti, G. Tamburrini, L. Massimi, M. Caldarelli, C. Di Rocco, I. Messana, M. Castagnola, C. Desiderio (2014)
  Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid
  in Journal of proteome research (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• I. Inserra, F. Iavarone, C. Martelli, L. D'Angelo, D. Delfino, D.V. Rossetti, G. Tamburrini, L. Massimi, M. Caldarelli, C. Di Rocco, I. Messana, M. Castagnola, C. Desiderio (literal)

Pagina inizio

• 4594 (literal)

Pagina fine

• 4606 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Journal of proteome research (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Istituto di Biochimica e Biochimica Clinica, Facoltà di Medicina, Università Cattolica del Sacro Cuore , Rome 00168, Italy (literal)

Titolo

• Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid (literal)

Abstract

• Liquid chromatography in coupling with high-resolution ESI-LTQ-Orbitrap mass spectrometry was applied for a proteomic study of pediatric pilocytic astrocytoma brain tumor intracystic fluid by an integrated top-down/bottom-up platform. Both of the proteomic strategies resulted comple-mentary and support each other in contributing to a wide characterization of the protein and peptide content of the tumorfluid. Top-down approach allowed to identify several proteins and peptides involved in different biological activities together with the characterization of interesting proteoforms such as fibrinopeptide A and its truncated form,fibrinopeptide B, complement C3f fragments,?-thymosin peptides, ubiquitin,several apolipoproteins belonging to A and C families,apolipoprotein J and D, and cystatin C. Of particular interest resulted the identification of a N-terminal truncated cystatin C proteoform, likely involved in immune response mechanism modulations and the identification of oxidized and glycosylated apolipoproteins including disulfie bridge dimeric forms. The bottom-up approach confirmed some of the experimental datafindingstogether with adding the characterization of high-molecular-mass proteins in the samples. These data could contribute toelucidate the molecular mechanisms involved in onset and progression of the disease and cyst development. (literal)

Prodotto di

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Proteomica salivare (PM.P06.008.002) (Modulo)

Autore CNR

• ANDREA DESIDERIO (Unità di personale interno)
• MASSIMO CASTAGNOLA (Persona)

Insieme di parole chiave

• Keywords of "Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto di chimica del riconoscimento molecolare (ICRM) (Istituto)
• Proteomica salivare (PM.P06.008.002) (Modulo)

Autore CNR di

• ANDREA DESIDERIO (Unità di personale interno)
• MASSIMO CASTAGNOLA (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of proteome research (Rivista)

Insieme di parole chiave di

• Keywords of "Proteomic Study of Pilocytic Astrocytoma Pediatric Brain Tumor Intracystic Fluid" (Insieme di parole chiave)