Squalene oxidation products: Monitoring the formation, characterisation and pro-oxidant activity (Articolo in rivista)

Type
Label
  • Squalene oxidation products: Monitoring the formation, characterisation and pro-oxidant activity (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1002/ejlt.201300506 (literal)
Alternative label
  • Naziri, Eleni; Consonni, Roberto; Tsimidou, Maria Z. (2014)
    Squalene oxidation products: Monitoring the formation, characterisation and pro-oxidant activity
    in European journal of lipid science and technology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Naziri, Eleni; Consonni, Roberto; Tsimidou, Maria Z. (literal)
Pagina inizio
  • 1400 (literal)
Pagina fine
  • 1411 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://onlinelibrary.wiley.com/doi/10.1002/ejlt.201300506/pdf (literal)
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  • 116 (literal)
Rivista
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  • 12 (literal)
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  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Aristotle University of Thessaloniki; Ist Studio Macromol (literal)
Titolo
  • Squalene oxidation products: Monitoring the formation, characterisation and pro-oxidant activity (literal)
Abstract
  • Squalene (SQ), a precursor of sterols and terpenoids is a functional lipid of high importance in the food and pharmaceutical sectors. SQ oxidation studies are rather limited compared with those for other olefins. The aim of the present study was to monitor the formation of SQ oxidation products under different conditions (temperature, air supply), to characterise the most abundant of them by spectroscopic techniques and then examine their pro-oxidant activity in a model lipid substrate. Squalane (SQA), the saturated analogue of SQ, was used as a reference compound. FT-MIR analysis indicated the presence of alcohols, epoxides, aldehydes, and ketones. GC-MS was used to characterise SQ primary oxidation and scission products. The presence of epoxides was further confirmed by means of H-1 NMR and C-13 NMR spectroscopy. It could be argued that SQ stability is due to its stereochemistry and specifically to the presence of methyl groups next to the double bonds. The pro-oxidant activity of SQ oxidation products was evident at 62 and 40 degrees C and suppressed only in the presence of primary antioxidants, not of SQ. The present work adds to the characterisation of SQ oxidised products. To our knowledge their pro-oxidant activity has never been examined before. (literal)
  • Practical applications: Characterisation of squalene oxidation products and assessment of their activity as pro-oxidants present both scientific interest regarding the kinetics and product identity as well as a practical impact in case this bioactive lipid is provided for consumption as a functional product. In the past, cholesterol oxidation products and more recently phytosterol ones attracted the interest of researchers, who studied the stability of the respective parent compounds for food safety reasons. (literal)
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