Effective Targeting of DC-SIGN by alpha-Fucosylamide Functionalized Gold Nanoparticles (Articolo in rivista)

Type
Label
  • Effective Targeting of DC-SIGN by alpha-Fucosylamide Functionalized Gold Nanoparticles (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/bc500467u (literal)
Alternative label
  • Daniela Arosio; Fabrizio Chiodo; Jose? J. Reina; Marcello Marelli; Soledad Penade?s; Yvette van Kooyk; Juan J. Garcia-Vallejo; Anna Bernardi (2014)
    Effective Targeting of DC-SIGN by alpha-Fucosylamide Functionalized Gold Nanoparticles
    in Bioconjugate chemistry
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Daniela Arosio; Fabrizio Chiodo; Jose? J. Reina; Marcello Marelli; Soledad Penade?s; Yvette van Kooyk; Juan J. Garcia-Vallejo; Anna Bernardi (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Daniela Arosio, Marcello Marelli, Anna Bernardi: CNR-Institute of Molecular Science and Technologies (ISTM), via Golgi 19, I-20133 Milan, Italy Fabrizio Chiodo, Soledad Penade?s: CIC biomaGUNE, Biofunctional Nanomaterials Unit, Laboratory of GlycoNanotechnology, Paseo Miramo?n 182, 20009 San Sebastia?n, Spain Yvette van Kooyk, Juan J. Garcia-Vallejo: VU University Medical Center, Department of Molecular Cell Biology & Immunology, van der Boechorststraat 7, 1081BT Amsterdam, The Netherlands Jose? J. Reina, Anna Bernardi: Universita? degli Studi di Milano, Dipartimento di Chimica, via Golgi 19, I-20133 Milan, Italy (literal)
Titolo
  • Effective Targeting of DC-SIGN by alpha-Fucosylamide Functionalized Gold Nanoparticles (literal)
Abstract
  • Dendritic Cells (DCs), the most potent antigenpresenting cells, play a critical role in the detection of invading pathogens, which are recognized also by multiple carbohydrate-specific receptors. Among them, DC-SIGN is one of the best characterized, with high-mannose and Lewis-type glycan specificity. In this study, we present a potent DC-SIGN targeting device developed using gold nanoparticles functionalized with ?-fucosyl-?-alanyl amide. The nanoparticles bound to cellular DC-SIGN and induced internalization as effectively as similar particles coated with comparable amounts of LewisX oligosaccharide. They were found to be neutral toward dendritic cell maturation and IL-10 production, thus envisaging a possible use as targeted imaging tools and antigen delivery devices. (literal)
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