http://www.cnr.it/ontology/cnr/individuo/prodotto/ID288979
Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone (Articolo in rivista)
- Type
- Label
- Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Alternative label
Pejin B., Iodice C.,Tommonaro G., Bogdanovic G., Kojic V. and De Rosa S. (2014)
Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone
in Natural product research (Online)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pejin B., Iodice C.,Tommonaro G., Bogdanovic G., Kojic V. and De Rosa S. (literal)
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- National Research Council of Italy, Institute of Biomolecular Chemistry, CNR-ICB, Pozzuoli-Naples, Italy
Department of Life Sciences, Institute for Multidisciplinary Research - IMSI, University of Belgrade, Serbia
Oncology Institute Vojvodina, University of Novi Sad, Sremska KamenicaSerbia (literal)
- Titolo
- Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone (literal)
- Abstract
- The cytotoxicity of 40-leucine-avarone, amino derivative of the sponge Dysidea avara
secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl
tetrazoliumbromide assay in vitro against seven human solid tumours for the first time. The
compound tested induced dose-dependent cytotoxic response in all cancer cells showing
better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40mM and
9.62mM, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and
ERnegativeMDA-MB-231 cells (IC50 11.64mMand 17.31mM, respectively), the prostate
adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24mM and
15.54mM, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5
cell line at the concentrations used. According to experimental data obtained, the
sesquiterpenoid quinone structure of avarone may inspire development of new drug-like
substances with improved cytotoxicity on lung cancer in humans (literal)
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