Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone (Articolo in rivista)

Type
Label
  • Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pejin B., Iodice C.,Tommonaro G., Bogdanovic G., Kojic V. and De Rosa S. (2014)
    Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone
    in Natural product research (Online)
    (literal)
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  • Pejin B., Iodice C.,Tommonaro G., Bogdanovic G., Kojic V. and De Rosa S. (literal)
Pagina inizio
  • 347 (literal)
Pagina fine
  • 350 (literal)
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  • 28 (literal)
Rivista
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  • 5 (literal)
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  • National Research Council of Italy, Institute of Biomolecular Chemistry, CNR-ICB, Pozzuoli-Naples, Italy Department of Life Sciences, Institute for Multidisciplinary Research - IMSI, University of Belgrade, Serbia Oncology Institute Vojvodina, University of Novi Sad, Sremska KamenicaSerbia (literal)
Titolo
  • Further in vitro evaluation of cytotoxicity of the marine natural product derivative 4'-leucine-avarone (literal)
Abstract
  • The cytotoxicity of 40-leucine-avarone, amino derivative of the sponge Dysidea avara secondary metabolite avarone, was evaluated by 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl tetrazoliumbromide assay in vitro against seven human solid tumours for the first time. The compound tested induced dose-dependent cytotoxic response in all cancer cells showing better activity towards the lung A-549 and colon HT-29 cell lines (IC50 7.40mM and 9.62mM, respectively) than towards the breast adenocarcinoma ER positive MCF-7 and ERnegativeMDA-MB-231 cells (IC50 11.64mMand 17.31mM, respectively), the prostate adenocarcinoma PC-3 and epiteloid cervix carcinoma HeLa cells (IC50 14.24mM and 15.54mM, respectively). No toxicity was found towards the foetal lung fibroblast MRC-5 cell line at the concentrations used. According to experimental data obtained, the sesquiterpenoid quinone structure of avarone may inspire development of new drug-like substances with improved cytotoxicity on lung cancer in humans (literal)
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