Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.ygeno.2014.03.003 (literal)

Alternative label

• Ambra R.; Manca S.; Palumbo M.C.; Leoni G.; Natarelli L.; De Marco A.; Consoli A.; Pandolfi A.; Virgili F. (2014)
  Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression
  in Genomics (S. Diego Calif.); Academic Press Inc., Elsevier Science, San Diego (Stati Uniti d'America)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ambra R.; Manca S.; Palumbo M.C.; Leoni G.; Natarelli L.; De Marco A.; Consoli A.; Pandolfi A.; Virgili F. (literal)

Pagina inizio

• 337 (literal)

Pagina fine

• 348 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/inward/record.url?eid=2-s2.0-84902124010&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 103 (literal)

Rivista

• Genomics (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 5-6 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Food and Nutrition Center of the Agricultural Research Council - CRA-NUT, via Ardeatina 546, 00178 Rome, Italy; Institute for Computing Applications M. Picone, National Research Council of Italy (CNR), via dei Taurini 19, 00185 Rome, Italy; Department of Experimental and Clinical Sciences, University G. d'Annunzio, Aging Research Center, Center of Excellence for Aging, G. d'Annunzio University Foundation, Chieti-Pescara, Italy; Department of Medicine and Aging Sciences, University G. d'Annunzio, Aging Research Center, Center of Excellence for Aging, G. d'Annunzio University Foundation, Chieti-Pescara, Italy (literal)

Titolo

• Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression (literal)

Abstract

• Within the complex pathological picture associated to diabetes, high glucose (HG) has \". per se\" effects on cells and tissues that involve epigenetic reprogramming of gene expression. In fetal tissues, epigenetic changes occur genome-wide and are believed to induce specific long term effects. Human umbilical vein endothelial cells (HUVEC) obtained at delivery from gestational diabetic women were used to study the transcriptomic effects of chronic hyperglycemia in fetal vascular cells using Affymetrix microarrays. In spite of the small number of samples analyzed (n=6), genes related to insulin sensing and extracellular matrix reorganization were found significantly affected by HG. Quantitative PCR analysis of gene promoters identified a significant differential DNA methylation in TGFB2. Use of Ea.hy926 endothelial cells confirms data on HUVEC. Our study corroborates recent evidences suggesting that epigenetic reprogramming of gene expression occurs with persistent HG and provides a background for future investigations addressing genomic consequences of chronic HG. © 2014 Elsevier Inc. (literal)

Editore

• Academic Press Inc., Elsevier Science (Editore)

Prodotto di

• Modellizzazione quantitativa di sistemi biologici complessi (SV.P18.002.001) (Modulo)
• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)

Autore CNR

• MARIA CONCETTA PALUMBO (Persona)

Insieme di parole chiave

• Keywords of "Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression" (Insieme di parole chiave)

Incoming links:

Prodotto

• Istituto per le applicazioni del calcolo \"Mauro Picone\" (IAC) (Istituto)
• Modellizzazione quantitativa di sistemi biologici complessi (SV.P18.002.001) (Modulo)

Autore CNR di

• MARIA CONCETTA PALUMBO (Persona)

Editore di

• Academic Press Inc., Elsevier Science (Editore)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Genomics (Rivista)

Insieme di parole chiave di

• Keywords of "Transcriptome analysis of human primary endothelial cells (HUVEC) from umbilical cords of gestational diabetic mothers reveals candidate sites for an epigenetic modulation of specific gene expression" (Insieme di parole chiave)