Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol (Articolo in rivista)

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  • Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Alternative label
  • Pejin B.; Iodice C.; Tommonaro G.; De Rosa S.; Pejin B.; Stanimirovic B.; Ciric A.; Glamoclija J.; Nikolic M.; Sokovic M. (2014)
    Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol
    in Current pharmaceutical biotechnology (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pejin B.; Iodice C.; Tommonaro G.; De Rosa S.; Pejin B.; Stanimirovic B.; Ciric A.; Glamoclija J.; Nikolic M.; Sokovic M. (literal)
Pagina inizio
  • 583 (literal)
Pagina fine
  • 588 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84907184482&partnerID=q2rCbXpz (literal)
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  • 15 (literal)
Rivista
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  • 6 (literal)
Note
  • Scopu (literal)
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  • National Research Council of Italy, Institute of Biomolecular Chemistry, CNR-ICB, Pozzuoli-Naples, Italy; University of Belgrade, Institute for Multidisciplinary Research, IMSI, Department of Life Sciences, Belgrade, Serbia; Institute MOL Ltd, Stara Pazova, Serbia; University of Belgrade, Institute for Biological Research Sinisa Stankovic, IBISS, Department of Plant Physiology, Mycological Laboratory, Belgrade, Serbia (literal)
Titolo
  • Further in vitro evaluation of antimicrobial activity of the marine sesquiterpene hydroquinone avarol (literal)
Abstract
  • This work extends in vitro screening of antimicrobial activity of the sesquiterpene hydroquinone avarol, a main secondary metabolite of the Mediterranean sponge species Dysidea avara. The antimicrobial activity was in part evaluated by microdilution method against selected bacterial and fungal strains. Additionally, the screening included evaluation of anti-quorum sensing (anti-QS) effects. At a different extent avarol was proven to be active against all the microorganisms tested (MIC 0.002-0.008 mg/mL and MBC 0.004-0.016 mg/mL; MIC 0.004-0.015 mg/mL and MFC 0.008-0.030 mg/mL; respectively). This marine natural product also showed moderate anti-QS effects, reducing Pseudomonas aeruginosa PAO1 biofilm formation (75%), its twitching and protrusions motilities as well as pyocianin production (39%). According to the best of our knowledge, this is the first report both on avarol anti Gram-negative bacterial activity and anti-QS effects. (literal)
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