http://www.cnr.it/ontology/cnr/individuo/prodotto/ID288397
Enantioselective synthesis of 1-vinyltetrahydroisoquinolines through palladium-catalysed intramolecular allylic amidation with chiral PhthalaPhos ligands (Articolo in rivista)
- Type
- Label
- Enantioselective synthesis of 1-vinyltetrahydroisoquinolines through palladium-catalysed intramolecular allylic amidation with chiral PhthalaPhos ligands (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1016/j.tetasy.2014.04.018 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Pignataro L.; Marelli E.; Gennari C.; Ferraccioli R. (literal)
- Pagina inizio
- Pagina fine
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-84902141227&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
- Note
- ISI Web of Science (WOS) (literal)
- Scopu (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
- Università Degli Studi di Milano, Dipartimento di Chimica, Via C. Golgi, 19, 20133 Milano, Italy; CNR-Istituto di Scienze e Tecnologie Molecolari (ISTM), Via C. Golgi, 19, 20133 Milano, Italy (literal)
- Titolo
- Enantioselective synthesis of 1-vinyltetrahydroisoquinolines through palladium-catalysed intramolecular allylic amidation with chiral PhthalaPhos ligands (literal)
- Abstract
- The PhthalaPhos ligands, chiral BINOL monophosphites endowed with a phthalamide group, have been screened in the synthesis of 1- vinyltetrahydroisoquinolines by intramolecular palladium-catalysed asymmetric allylic amidation (AAA) of achiral tosylamidocarbonates. Identification of the best ligand followed by optimisation of the reaction conditions allowed the desired product to be obtained with up to 83% ee. Remarkably, the reaction is stereoconvergent, affording the same enantiomer of the desired product regardless of the geometry of the allylic carbonate's double bond, which allows, in principle, the use of E/Z mixtures. © 2014 Elsevier Ltd. All rights reserved. (literal)
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- Autore CNR
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