The GM1 Ganglioside Forms GM1-Rich Gel Phase Microdomains within Lipid Rafts (Articolo in rivista)

Type
Label
  • The GM1 Ganglioside Forms GM1-Rich Gel Phase Microdomains within Lipid Rafts (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3390/coatings4030450 (literal)
Alternative label
  • Becucci, Lucia; Vizza, Francesco; Duarte, Yolanda; Guidelli, Rolando (2014)
    The GM1 Ganglioside Forms GM1-Rich Gel Phase Microdomains within Lipid Rafts
    in Coatings (Basel); MDPI AG, Basel (Swaziland)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Becucci, Lucia; Vizza, Francesco; Duarte, Yolanda; Guidelli, Rolando (literal)
Pagina inizio
  • 450 (literal)
Pagina fine
  • 464 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 4 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Istituto di Chimica dei Composti Organo Metallici, Consiglio Nazionale delle Ricerche, Via Madonna del Piano 10, 50019 Sesto Fiorentino (Firenze), Italy; Department of Chemistry, Florence University, Sesto Fiorentino (Firenze) 50019, Italy; Retired. (literal)
Titolo
  • The GM1 Ganglioside Forms GM1-Rich Gel Phase Microdomains within Lipid Rafts (literal)
Abstract
  • Mercury-supported, self-assembled monolayers (SAMs) of the sole dioleoylphosphatidylcholine (DOPC) and of a raft-forming mixture of DOPC, cholesterol (Chol) and palmitoylsphingomyelin (PSM) of (59:26:15) mol% composition, were investigated by electrochemical impedance spectroscopy (EIS), both in the absence and in the presence of the monosialoganglioside GM1. The impedance spectra of these four SAMs were fitted by a series of parallel combinations of a resistance and a capacitance (RC meshes) and displayed on plots of ?Z? against -?Z?, where Z? and Z? are the in-phase and quadrature components of the impedance and ? is the angular frequency. A comparison among these different impedance spectra points to the formation of GM1-rich gel phase microdomains within the lipid rafts of the DOPC/Chol/PSM mixture, thanks to the unique molecular-level smooth support provided by mercury, which allows EIS to detect the protruding gel phase microdomains by averaging them over a macroscopically large area. (literal)
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