http://www.cnr.it/ontology/cnr/individuo/prodotto/ID288128

Iron oxide superparamagnetic nanoparticles conjugated with a conformationally blocked alpha-Tn antigen mimetic for macrophage activation (Articolo in rivista)

Type

Label

Iron oxide superparamagnetic nanoparticles conjugated with a conformationally blocked alpha-Tn antigen mimetic for macrophage activation (Articolo in rivista) (literal)

Anno

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

Alternative label

Manuelli, Massimo; Fallarini, Silvia; Lombardi, Grazia; Sangregorio, Claudio; Nativi, Cristina; Richichi, Barbara (2014)
Iron oxide superparamagnetic nanoparticles conjugated with a conformationally blocked alpha-Tn antigen mimetic for macrophage activation
in Nanoscale (Print); ROYAL SOC CHEMISTRY, THOMAS GRAHAM HOUSE,, CAMBRIDGE CB4 0WF, CAMBS, ENGLAND (Regno Unito)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Manuelli, Massimo; Fallarini, Silvia; Lombardi, Grazia; Sangregorio, Claudio; Nativi, Cristina; Richichi, Barbara (literal)

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University of Florence; University of Florence; Consiglio Nazionale delle Ricerche (CNR); University of Eastern Piedmont Amedeo Avogadro (literal)

Titolo

Iron oxide superparamagnetic nanoparticles conjugated with a conformationally blocked alpha-Tn antigen mimetic for macrophage activation (literal)

Abstract

Among new therapies to fight tumors, immunotherapy is still one of the most promising and intriguing. Thanks to the ongoing structural elucidation of several tumor antigens and the development of innovative antigen carriers, immunotherapy is in constant evolution and it is largely used either alone or in synergy with chemotherapy/radiotherapy. With the aim to develop fully synthetic immunostimulants we have recently developed a mimetic of the alpha-Tn mucin antigen, a relevant tumor antigen. The C-4(1) blocked mimetic 1, unique example of an alpha-Tn mimetic antigen, was functionalized with an omega-phosphonate linker and used to decorate iron oxide superparamagnetic nanoparticles (MNPs), employed as multivalent carriers. MNPs, largely exploited for supporting and carrying biomolecules, like antibodies, drugs or antigens, consent to combine in the same nanometric system the main features of an inorganic magnetic core with a bioactive organic coating. The superparamagnetic glyconanoparticles obtained, named GMNPs, are indeed biocompatible and immunoactive, and they preserve suitable characteristics for use as heat mediators in the magnetic fluid hyperthermia (MFH) treatment of tumors. All together these properties make GMNPs attracting devices for innovative tumor treatment. (literal)

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