Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/j.jconrel.2013.03.012 (literal)

Alternative label

• Duchi, Serena; Sotgiu, Giovanna; Lucarelli, Enrico; Ballestri, Marco; Dozza, Barbara; Santi, Spartaco; Guerrini, Andrea; Dambruoso, Paolo; Giannini, Sandro; Donati, Davide Maria; Ferroni, Claudia; Varchi, Greta (2013)
  Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma
  in Journal of controlled release
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Duchi, Serena; Sotgiu, Giovanna; Lucarelli, Enrico; Ballestri, Marco; Dozza, Barbara; Santi, Spartaco; Guerrini, Andrea; Dambruoso, Paolo; Giannini, Sandro; Donati, Davide Maria; Ferroni, Claudia; Varchi, Greta (literal)

Pagina inizio

• 225 (literal)

Pagina fine

• 237 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.scopus.com/record/display.url?eid=2-s2.0-84877047183&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 168 (literal)

Rivista

• Journal of controlled release (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IRCCS Istituto Ortopedico Rizzoli, Bologna; Consiglio Nazionale delle Ricerche; Alma Mater Studiorum Universita di Bologna; Laboratory of Cell Biology and Electron Microscopy (literal)

Titolo

• Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma (literal)

Abstract

• Mesenchymal stem cells (MSC) have the unique ability to home and engraft in tumor stroma. These features render them potentially a very useful tool as targeted delivery vehicles which can deliver therapeutic drugs to the tumor stroma. In the present study, we investigate whether fluorescent core-shell PMMA nanoparticles (FNPs) post-loaded with a photosensitizer, namely meso-tetrakis (4-sulfonatophenyl) porphyrin (TPPS) and uploaded by MSC could trigger osteosarcoma (OS) cell death in vitro upon specific photoactivation. In co-culture studies we demonstrate using laser confocal microscopy and time lapse imaging, that only after laser irradiation MSC loaded with photosensitizer- coated fluorescent NPs (TPPS@FNPs) undergo cell death and release reactive oxygen species (ROS) which are sufficient to trigger cell death of all OS cells in the culture. These results encourage further studies aimed at proving the efficacy of this novel tri-component system for PDT applications. © 2013 Elsevier B.V. (literal)

Prodotto di

• Institute of molecular genetics (IGM) (Istituto)
• Bersagli molecolari per il controllo della progressione tumorale (ME.P03.012.001) (Modulo)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Sintesi e caratterizzazione mediante metodologie chimiche innovative, di scaffold molecolari per l'individuazione di nuove molecole biologicamente attive. (PM.P03.011.002) (Modulo)

Autore CNR

• GIOVANNA SOTGIU (Persona)
• MARCO BALLESTRI (Persona)
• ANDREA GUERRINI (Persona)
• SPARTACO SANTI (Persona)
• PAOLO DAMBRUOSO (Persona)
• GRETA VARCHI (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular genetics (IGM) (Istituto)
• Institute for organic syntheses and photoreactivity (ISOF) (Istituto)
• Bersagli molecolari per il controllo della progressione tumorale (ME.P03.012.001) (Modulo)
• Sintesi e caratterizzazione mediante metodologie chimiche innovative, di scaffold molecolari per l'individuazione di nuove molecole biologicamente attive. (PM.P03.011.002) (Modulo)

Autore CNR di

• SPARTACO SANTI (Persona)
• GRETA VARCHI (Unità di personale interno)
• MARCO BALLESTRI (Persona)
• GIOVANNA SOTGIU (Persona)
• ANDREA GUERRINI (Persona)
• PAOLO DAMBRUOSO (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Journal of controlled release (Rivista)

Insieme di parole chiave di

• Keywords of "Mesenchymal stem cells as delivery vehicle of porphyrin loaded nanoparticles: Effective photoinduced in vitro killing of osteosarcoma" (Insieme di parole chiave)