Electrophysiology Investigation of Trichogin GA IV Activity in Planar Lipid Membranes Reveals Ion Channels of Well-Defined Size (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Electrophysiology Investigation of Trichogin GA IV Activity in Planar Lipid Membranes Reveals Ion Channels of Well-Defined Size (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1002/cbdv.201300334 (literal)

Alternative label

• Iftemi, Sorana; De Zotti, Marta; Formaggio, Fernando; Toniolo, Claudio; Stella, Lorenzo; Luchian, Tudor (2014)
  Electrophysiology Investigation of Trichogin GA IV Activity in Planar Lipid Membranes Reveals Ion Channels of Well-Defined Size
  in Chemistry & biodiversity (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Iftemi, Sorana; De Zotti, Marta; Formaggio, Fernando; Toniolo, Claudio; Stella, Lorenzo; Luchian, Tudor (literal)

Pagina inizio

• 1069 (literal)

Pagina fine

• 1077 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 11 (literal)

Rivista

• Chemistry & biodiversity (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 9 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 7 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Department of Physics, Laboratory of Molecular Biophysics and Medical Physics, Alexandru I. Cuza University, 11, Blvd. Carol I, RO-700506 Iasi; ICB, Padova Unit, CNR, Department of Chemistry, University of Padova, IT-35131 Padova; Department of Chemical Sciences and Technologies, University of Rome \"Tor Vergata\", via della Ricerca Scientifica 1, IT-00133 Rome; Department of Interdisciplinary Science, Alexandru I. Cuza University, RO-700506 Iasi (literal)

Titolo

• Electrophysiology Investigation of Trichogin GA IV Activity in Planar Lipid Membranes Reveals Ion Channels of Well-Defined Size (literal)

Abstract

• Trichogin GA IV, an antimicrobial peptaibol, exerts its function by augmenting membrane permeability, but the molecular aspects of its pore-forming mechanism are still debated. Several lines of evidence indicate a 'barrel-stave' channel structure, similar to that of alamethicin, but the length of a trichogin helix is too short to span a normal bilayer. Herein, we present electrophysiology measurements in planar bilayers, showing that trichogin does form channels of a well-defined size (R = 4.2 109 W; corresponding at least to a trimeric aggregate) that span the membrane and allow ion diffusion, but do not exhibit voltage-dependent rectification, unlike those of alamethicin. (literal)

Prodotto di

• Peptidi da amminoacidi non proteici con potenzialità in nanomedicina (PM.P01.021.001) (Modulo)
• Istituto di chimica biomolecolare (ICB) (Istituto)

Autore CNR

• FERNANDO FORMAGGIO (Unità di personale esterno)
• CLAUDIO TONIOLO (Persona)

Incoming links:

Prodotto

• Istituto di chimica biomolecolare (ICB) (Istituto)
• Peptidi da amminoacidi non proteici con potenzialità in nanomedicina (PM.P01.021.001) (Modulo)

Autore CNR di

• CLAUDIO TONIOLO (Persona)
• FERNANDO FORMAGGIO (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Chemistry & biodiversity (Rivista)