A mathematical model of skeletal muscle disease and immune response in the mdx mouse (Articolo in rivista)

Type
Label
  • A mathematical model of skeletal muscle disease and immune response in the mdx mouse (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1155/2014/871810 (literal)
Alternative label
  • Jarrah A.S.; Castiglione F.; Evans N.P.; Grange R.W.; Laubenbacher R. (2014)
    A mathematical model of skeletal muscle disease and immune response in the mdx mouse
    in BioMed Research International [electronic resource]
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Jarrah A.S.; Castiglione F.; Evans N.P.; Grange R.W.; Laubenbacher R. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84903641332&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 2014 (literal)
Rivista
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Mathematics and Statistics, American University of Sharjah, Sharjah 26666, United Arab Emirates; Institute for Applied Mathematics, National Research Council of Italy, 00185 Rome, Italy; Department of Population Health Sciences, Virginia Tech, Blacksburg, VA 24060, United States; Department of Human Nutrition, Foods and Exercise, Virginia Tech, Blacksburg, VA 24060, United States; Center of Quantitative Medicine, University of Connecticut Health Center, Farmington, CT 06030, United States; Jackson Laboratory for Genomic Medicine, Farmington CT 06030, United States (literal)
Titolo
  • A mathematical model of skeletal muscle disease and immune response in the mdx mouse (literal)
Abstract
  • Duchenne muscular dystrophy (DMD) is a genetic disease that results in the death of affected boys by early adulthood. The genetic defect responsible for DMD has been known for over 25 years, yet at present there is neither cure nor effective treatment for DMD. During early disease onset, the mdx mouse has been validated as an animal model for DMD and use of this model has led to valuable but incomplete insights into the disease process. For example, immune cells are thought to be responsible for a significant portion of muscle cell death in the mdx mouse; however, the role and time course of the immune response in the dystrophic process have not been well described. In this paper we constructed a simple mathematical model to investigate the role of the immune response in muscle degeneration and subsequent regeneration in the mdx mouse model of Duchenne muscular dystrophy. Our model suggests that the immune response contributes substantially to the muscle degeneration and regeneration processes. Furthermore, the analysis of the model predicts that the immune system response oscillates throughout the life of the mice, and the damaged fibers are never completely cleared. © 2014 Abdul Salam Jarrah et al. (literal)
Prodotto di
Autore CNR

Incoming links:


Prodotto
Autore CNR di
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it