http://www.cnr.it/ontology/cnr/individuo/prodotto/ID287452
Multi-scale Simulation of T Helper Lymphocyte Differentiation (Articolo in rivista)
- Type
- Label
- Multi-scale Simulation of T Helper Lymphocyte Differentiation (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Alternative label
Tieri P, Prana V, Colombo T, Daniele Santoni, Castiglione F (2014)
Multi-scale Simulation of T Helper Lymphocyte Differentiation
in Lecture notes in computer science
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- Tieri P, Prana V, Colombo T, Daniele Santoni, Castiglione F (literal)
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- http://www.scopus.com/record/display.url?eid=2-s2.0-84909641449&origin=inward (literal)
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- Rivista
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- CNR Consiglio Nazionale delle Ricerche,
IAC Istituto per le Applicazioni del Calcolo, Roma, Italy
CNR Consiglio Nazionale delle Ricerche,
IASI Istituto di Analisi dei Sistemi e Informatica, Roma, Italy (literal)
- Titolo
- Multi-scale Simulation of T Helper Lymphocyte Differentiation (literal)
- Abstract
- The complex differentiation process of the CD4+ T helper lymphocytes shapes the form and the range of the immune response to different antigenic challenges. Few mathematical and computational models have addressed this key phenomenon. We here present a multiscale approach in which two different levels of description, i.e. a gene regulatory network model and an agent-based simulator for cell population dynamics, are integrated into a single immune system model. We illustrate how such model integration allows bridging a gap between gene level information and cell level population, and how the model is able to describe a coherent immunological behaviour when challenged with different stimuli. (literal)
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