A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene (Articolo in rivista)

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  • A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.3892/or.2013.2835 (literal)
Alternative label
  • Moon H, Cho S, Loh TJ, Zhou J, Ghigna C, Biamonti G, Green MR, Zheng X, Shen H. (2014)
    A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene
    in Oncology Reports (Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Moon H, Cho S, Loh TJ, Zhou J, Ghigna C, Biamonti G, Green MR, Zheng X, Shen H. (literal)
Pagina inizio
  • 450 (literal)
Pagina fine
  • 455 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84891948317&partnerID=q2rCbXpz (literal)
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  • 31 (literal)
Rivista
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  • 1 (literal)
Note
  • Scopu (literal)
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  • School of Life Sciences, Gwangju Institute of Science and Technology, 1 Oryoung-Dong, Gwangju 500-712, South Korea; Jiangsu Key Laboratory of Neuroregeneration, Nantong University, 19 Qixiu Road, Nantong 226001, China; Institute of Molecular Genetics, National Research Council, I-27100 Pavia, Italy; Howard Hughes Medical Institute, Programs in Gene Function and Expression and Molecular Medicine, University of Massachusetts Medical School, Worcester, MA 01605, United States (literal)
Titolo
  • A 2-nt RNA enhancer on exon 11 promotes exon 11 inclusion of the Ron proto-oncogene (literal)
Abstract
  • Ron is a human receptor for the macrophage-stimulating protein (MSP). Exon 11 skipping of Ron pre-mRNA produces the Ron?165 protein that has a deletion of a 49 amino acid region in the ?-chain extracellular domain. Ron?165 is constitutively active even in the absence of its ligand. Through stepwise deletion analysis, we identified a 2-nt RNA enhancer, which is located 74 nt upstream from the 5? splice site of exon 11, for exon 11 inclusion. Through double-base and single-base substitution analysis of the 2-nt RNA, we demonstrated that the GA, CC, UG and AC dinucleotides on exon 11, in addition to the wild-type AG sequence, function as enhancers for exon 11 inclusion of the Ron pre-mRNA. (literal)
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