Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity (Articolo in rivista)

Type
Label
  • Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/ml5000959 (literal)
Alternative label
  • Giacomini E.; Nebbioso A.; Ciotta A.; Ianni C.; Falchi F.; Roberti M.; Tolomeo M.; Grimaudo S.; Cristina A.D.; Pipitone R.M.; Altucci L.; Recanatini M. (2014)
    Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity
    in ACS medicinal chemistry letters
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Giacomini E.; Nebbioso A.; Ciotta A.; Ianni C.; Falchi F.; Roberti M.; Tolomeo M.; Grimaudo S.; Cristina A.D.; Pipitone R.M.; Altucci L.; Recanatini M. (literal)
Pagina inizio
  • 973 (literal)
Pagina fine
  • 978 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84907515205&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Pharmacy and Biotechnology, University of Bologna, Via Belmeloro 6, Bologna, 40126, Italy; Department of Drug Discovery and Development, Italian Institute of Technology, Via Morego 30, Genova, 16163, Italy; Department of Biochemistry, Biophysics and General Pathology, Second University of Naples, Vico L. De Crecchio 7, Naples, 80138, Italy; Interdepartmental Center of Research in Clinical Oncology, Department of Infectious Diseases, University of Palermo, Via del Vespro 129, Palermo, 90127, Italy; Laboratory of Molecular Pathology, Institute of Gastroenterology, University of Palermo, Piazza delle Cliniche 2, Palermo, 90127, Italy; Institute of Genetics and Biophysics, IGB, Via Pietro Castellino 111, Naples, 80131, Italy (literal)
Titolo
  • Novel antiproliferative chimeric compounds with marked histone deacetylase inhibitory activity (literal)
Abstract
  • Given our interest in finding potential antitumor agents and in view of the multifactorial mechanistic nature of cancer, in the present work, taking advantage of the multifunctional ligands approach, new chimeric molecules were designed and synthesized by combining in single chemical entities structural features of SAHA, targeting histone deacetylases (HDACs), with substituted stilbene or terphenyl derivatives previously obtained by us and endowed with antiproliferative and pro-apoptotic activity. The new chimeric derivatives were characterized with respect to their cytotoxic activity and their effects on cell cycle progression on different tumor cell lines, as well as their HDACs inhibition. Among the other, trans-6 showed the most interesting biological profile, as it exhibited a strong pro-apoptotic activity in tumor cell lines in comparison with both of its parent compounds and a marked HDAC inhibition. (literal)
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