http://www.cnr.it/ontology/cnr/individuo/prodotto/ID287121
Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies (Articolo in rivista)
- Type
- Label
- Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.4161/nucl.36289 (literal)
- Alternative label
Camozzi D, Capanni C, Cenni V, Mattioli E, Columbaro M, Squarzoni S, Lattanzi G. (2014)
Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies
in Nucleus (Austin, Tex. : Print)
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Camozzi D, Capanni C, Cenni V, Mattioli E, Columbaro M, Squarzoni S, Lattanzi G. (literal)
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- http://www.scopus.com/inward/record.url?eid=2-s2.0-84908206318&partnerID=q2rCbXpz (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
- Rivista
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- CNR Institute for Molecular Genetics, Unit of Bologna and SC Laboratory of Musculoskeletal Cell Biology, Rizzoli Orthopedic Institute, Bologna, Italy (literal)
- Titolo
- Diverse lamin-dependent mechanisms interact to control chromatin dynamics: Focus on laminopathies (literal)
- Abstract
- Interconnected functional strategies govern chromatin dynamics in eukaryotic cells. In this context, Aand B type lamins, the nuclear intermediate filaments, act on diverse platforms involved in tissue homeostasis. On the nuclear side, lamins elicit large scale or fine chromatin conformational changes, affect DNAdamage response factors and transcription factor shuttling. On the cytoplasmic side, bridging-molecules, the LINC complex, associate with lamins to coordinate chromatin dynamics with cytoskeleton and extra-cellular signals.,Consistent with such a fine tuning, lamin mutations and/or defects in their expression or post-translational processing, as well as mutations in lamin partner genes, cause a heterogeneous group of diseases known as laminopathies. They include muscular dystrophies, cardiomyopathy, lipodystrophies, neuropathies, and progeroid syndromes. The study of chromatin dynamics under pathological conditions, which is summarized in this review, is shedding light on the complex and fascinating role of the nuclear lamina in chromatin regulation. (literal)
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