Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease (Articolo in rivista) (literal)

Anno

• 2015-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.3109/09637486.2014.959896 (literal)

Alternative label

• Valentina Bravatà (2015)
  Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease
  in International journal of food sciences and nutrition (Online)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Valentina Bravatà (literal)

Pagina inizio

• 43 (literal)

Pagina fine

• 49 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 66 (literal)

Rivista

• International journal of food sciences and nutrition (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 1 (literal)

Note

• PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• IBFM-CNR, LATO, Cefalù (PA), Italy. (literal)

Titolo

• Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease (literal)

Abstract

• Abstract Breast cancer (BC) represents a highly heterogeneous tumour at both the clinical and molecular levels. Single-nucleotide polymorphisms (SNPs) of the folate-metabolising enzyme methylenetetrahydrofolate-reductase (MTHFR) may modify the association between folate intake and BC and influence plasma folate concentration. The role of folate in BC is equivocal, association studies between the common MTHFR SNPs C677T and A1298C and BC risk are controversial. In this study, I have reviewed observed associations between folate intake, as well as its blood levels, and BC. The purpose of this review is to analyse the role of folate and the two SNPs associated with reduced enzyme activity in BC. I explored the most relevant and updated work that emphasises positive and negative associations among these variables. My findings indicate that no definitive conclusions can be drawn from the studies on this topic. However, this manuscript highlights variables that could be useful to explore in further association analyses. (literal)

Prodotto di

• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)
• Institute of molecular bioimaging and physiology (IBFM) (Istituto)

Autore CNR

• VALENTINA BRAVATA' (Persona)

Insieme di parole chiave

• Keywords of "Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of molecular bioimaging and physiology (IBFM) (Istituto)
• Proteomica differenziale di tessuti patologici e fluidi biologici per la comprensione della biologia dei sistemi (ME.P06.026.002) (Modulo)

Autore CNR di

• VALENTINA BRAVATA' (Persona)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• International journal of food sciences and nutrition (Rivista)

Insieme di parole chiave di

• Keywords of "Controversial roles of methylenetetrahydrofolate reductase polymorphisms and folate in breast cancer disease" (Insieme di parole chiave)