http://www.cnr.it/ontology/cnr/individuo/prodotto/ID286437
Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-a? antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution (Articolo in rivista)
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- Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-a? antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution (Articolo in rivista) (literal)
- Anno
- 2014-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1371/journal.pone.0101474 (literal)
- Alternative label
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Mantile F.; Trovato M.; Santoni A.; Barba P.; Ottonello S.; De Berardinis P.; Prisco A. (literal)
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- Prisco *Corresponding Author (literal)
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- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
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- Institute of Genetics and Biophysics, CNR, Napoli, Italy; Institute of Protein Biochemistry, CNR, Napoli, Italy; Department of Life Sciences, University of Parma, Parma, Italy (literal)
- Titolo
- Alum and squalene-oil-in-water emulsion enhance the titer and avidity of anti-a? antibodies induced by multimeric protein antigen (1-11)E2, preserving the Igg1-skewed isotype distribution (literal)
- Abstract
- The development of active immunotherapy for Alzheimer's disease (AD) requires the identification of immunogens that can ensure a high titer antibody response toward A?, while minimizing the risks of adverse reactions. Multimeric protein (1-11)E2 induces a robust and persistent antibody response to A? in mice, when formulated in Freund's adjuvant. The goal of this translational study was to evaluate the immunogenicity of (1-11)E2 formulated in alum (Alhydrogel 2%), or in a squalene oil-in-water emulsion (AddaVax), or without adjuvant. A IgG1-skewed isotype distribution was observed for the anti-A? antibodies generated in mice immunized with either the non-adjuvanted or the adjuvanted vaccine, indicating that (1-11)E2 induces a Th2-like response in all tested conditions. Both Alhydrogel 2% and AddaVax enhanced the titer and avidity of the anti-A? response elicited by (1-11)E2. We conclude that (1-11)E2 is a promising candidate for anti-A? immunization protocols that include alum or squalene-oil-in-water emulsion, or no adjuvant. © 2014 Mantile et al. (literal)
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