Sulfonamides with Potent Inhibitory Action and Selectivity against the alpha-Carbonic Anhydrase from Vibrio cholerae (Articolo in rivista)

Type
Label
  • Sulfonamides with Potent Inhibitory Action and Selectivity against the alpha-Carbonic Anhydrase from Vibrio cholerae (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1021/ml500192a (literal)
Alternative label
  • Ceruso, Mariangela; Del Prete, Sonia; Alothman, Zeid; Capasso, Clemente; Supuran, Claudiu T. (2014)
    Sulfonamides with Potent Inhibitory Action and Selectivity against the alpha-Carbonic Anhydrase from Vibrio cholerae
    in ACS medicinal chemistry letters
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Ceruso, Mariangela; Del Prete, Sonia; Alothman, Zeid; Capasso, Clemente; Supuran, Claudiu T. (literal)
Pagina inizio
  • 826 (literal)
Pagina fine
  • 830 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 5 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 7 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Florence; Consiglio Nazionale delle Ricerche (CNR); King Saud University; University of Florence (literal)
Titolo
  • Sulfonamides with Potent Inhibitory Action and Selectivity against the alpha-Carbonic Anhydrase from Vibrio cholerae (literal)
Abstract
  • By using N-alpha-acetyl-L-lysine or GABA scaffolds and the conversion of the terminal amino group to the guanidine one, benzenesulfonamides incorporating water solubilizing moieties were synthesized. The new compounds were medium potency inhibitors of the cytosolic carbonic anhydrase (CA, EC 4.2.1.1) isoforms I and II, and highly effective, nanomolar inhibitors of the pathogenic bacterial alpha-CA from Vibrio cholerae. These sulfonamides possess good selectivity for inhibiting the bacterial over the mammalian isoforms and may be used as tools to understand the role of bacterial CAs in pathogenesis. (literal)
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