Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury (Articolo in rivista)

Type
Label
  • Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1007/s10157-013-0828-2 (literal)
Alternative label
  • Pisani A.; Sabbatini M.; Riccio E.; Rossano R.; Andreucci M.; Capasso C.; De Luca V.; Carginale V.; Bizzarri M.; Borrelli A.; Schiattarella A.; Santangelo M.; Mancini A. (2014)
    Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury
    in Clinical and experimental nephrology
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Pisani A.; Sabbatini M.; Riccio E.; Rossano R.; Andreucci M.; Capasso C.; De Luca V.; Carginale V.; Bizzarri M.; Borrelli A.; Schiattarella A.; Santangelo M.; Mancini A. (literal)
Pagina inizio
  • 424 (literal)
Pagina fine
  • 431 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84903380557&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 18 (literal)
Rivista
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  • 3 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Department of Nephrology, University Federico II of Naples, 80131 Naples, Italy; Department of Nephrology, Magna Graecia University, 88100 Catanzaro, Italy; CNR, Institute of Protein Biochemistry (IBP), 80131 Naples, Italy; Italian Space Agency, La Sapienza University, 00161 Rome, Italy; National Cancer Institute G. Pascale, 80131 Naples, Italy; Department of Surgery, University Federico II of Naples, 80131 Naples, Italy (literal)
Titolo
  • Effect of a recombinant manganese superoxide dismutase on prevention of contrast-induced acute kidney injury (literal)
Abstract
  • Background: Contrast media (CM)-induced nephropathy (CIN) is an acute deterioration of renal function following administration of CM mediated to a large extent by the increased production of ROS within the kidney. Aim of this study was to evaluate whether a novel isoform of a recombinant Manganese SOD (rMnSOD) could provide an effective protection against CIN; this molecule shares the same ability of physiological SODs in scavenging reactive oxygen species (ROS) but, due to its peculiar properties, enters inside the cells after its administration. Methods: We studied the effects rMnSOD on oxidative damage in a rat model of CIN in uninephrectomized rats, that were randomly assigned to 3 experimental Groups: Group CON, control rats treated with the vehicle of CM, Group HCM, rats treated with CM and Group SOD, rats treated with CM and rMnSOD. Results: In normal rats, pretreatment with rMnSOD, reduced renal superoxide anion production, induced by the activation of NAPDH oxidase, by 84 % (p < 0.001). In rats of Group HCM, ROS production was almost doubled compared to rat of Group CON (p < 0.01) but returned to normal values in rats of Group SOD, where a significant increase of SOD activity was detected (+16 % vs HCM, p < 0.05). Administration of CM determined a striking fall of GFR in rats of Group HCM (-70 %, p < 0.001 vs CON), greatly blunted in Group SOD (-28 % vs CON, p < 0.01); this was associated with a lower presence of both tubular necrosis and intratubular casts in SOD-treated rats (both p < 0.01 vs Group HCM). Conclusions: Our data indicate that rMnSOD is able to reduce renal oxidative stress, thus preventing the reduction of GFR and the renal histologic damage that follows CM administration. © 2013 Japanese Society of Nephrology. (literal)
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