Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice (Articolo in rivista)

Type
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  • Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1186/1746-6148-9-255 (literal)
Alternative label
  • Gargiulo S.; Gramanzini M.; Liuzzi R.; Greco A.; Brunetti A.; Vesce G. (2013)
    Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice
    in BMC veterinary research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Gargiulo S.; Gramanzini M.; Liuzzi R.; Greco A.; Brunetti A.; Vesce G. (literal)
Pagina inizio
  • 255 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url
  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84890268391&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 9 (literal)
Rivista
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  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Biostructures and Bioimages of the National Council of Research, Via T. De Amicis 95, Naples 80145, Italy; Department of Advanced Biomedical Sciences, University of Naples Federico II, Via Pansini 5, Naples 80145, Italy; CEINGE scarl, Via G. Salvatore 486, Naples 80145, Italy; Department of Veterinary Medicine and Animal Productions, University of Naples Federico II, Via Delpino 1, Naples 80137, Italy (literal)
Titolo
  • Effects of some anesthetic agents on skin microcirculation evaluated by laser Doppler perfusion imaging in mice (literal)
Abstract
  • Background: Anesthetic agents alter microcirculation, influencing tissue oxygenation and delivery of vital substrates. Laser Doppler perfusion imaging is a widespread technique in the field of microvascular research that can evaluate noninvasively and in real time the effects of environmental conditions, physical manipulations, diseases and treatments on peripheral perfusion. This study aims to evaluate laser Doppler perfusion imaging as a means to detect changes in skin microcirculation induced by some popular anesthetic agents in a murine model. Twenty-four age- and gender-matched healthy CD1 mice were examined by laser Doppler perfusion imaging. The skin microcirculatory response was measured at the level of plantar surfaces during isoflurane anesthesia with or without subsequent dexmedetomidine or acepromazine. At the end of the procedure, dexmedetomidine was reversed by atipamezole administration. Results: In all mice, skin blood flow under isoflurane anesthesia did not show significant differences over time (P = 0.1). The serial perfusion pattern and values following acepromazine or dexmedetomidine administration differed significantly (P < 0.05). Conclusions: We standardized a reliable laser Doppler perfusion imaging protocol to non-invasively assess changes in skin microcirculation induced by anesthesia in mice, considering the advantages and drawbacks of this technique and its translational value. © 2013 Gargiulo et al.; licensee BioMed Central Ltd. (literal)
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