Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambui cohort study of ageing (1997-2008) (Articolo in rivista)

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Label
  • Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambui cohort study of ageing (1997-2008) (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/hr.2012.175 (literal)
Alternative label
  • Leite, Maria Lea Correa; Lima-Costa, Maria Fernanda; Moriguchi, Emilio H. (2013)
    Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambui cohort study of ageing (1997-2008)
    in Hypertension research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Leite, Maria Lea Correa; Lima-Costa, Maria Fernanda; Moriguchi, Emilio H. (literal)
Pagina inizio
  • 270 (literal)
Pagina fine
  • 276 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 36 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 7 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 3 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Consiglio Nazionale delle Ricerche (CNR); Fundacao Oswaldo Cruz; Universidade Federal do Rio Grande do Sul (literal)
Titolo
  • Age-related trends of blood pressure levels by apolipoprotein E genotype: the Bambui cohort study of ageing (1997-2008) (literal)
Abstract
  • The role of apolipoprotein E (apoE) polymorphisms in regulating blood pressure (BP) is still not clear. The aim of this study was to examine longitudinal changes in BP levels by apoE genotypes in a population-based prospective cohort of elderly subjects, and explore interactions with plasma lipids and uric acid. Subjects whose apoE genes had been genotyped at baseline (1408, representing 80.8% of all the elderly residents in Bambui city, south-eastern Brazil; age range 60-95 years) were included in the analysis. Repeated BP measurements were obtained in four waves. Multi-level random-effects pattern-mixture models were used to evaluate the age-related BP trajectories, accounting for non-ignorable dropouts/deaths and handling heterogeneities as random parameter variations. Subjects with the epsilon 4/4 genotype and high levels of low-density lipoprotein cholesterol had higher systolic BP levels at 60 years of age than those with the other genotypes (154.5 vs. 133.2 mm Hg, P = 0.020), but this was not the case among the older subjects. Systolic BP increased more rapidly with age in the epsilon 2 carriers, leading to significantly higher levels among the oldest. This relationship seemed to be modulated by uric acid levels, as it was present in the subjects with the epsilon 2/3 genotype and high uric acid levels, and in those with the epsilon 2/4 genotype and low or normal uric acid levels. The differences in systolic BP between the genotypes were age dependent, and the shift between the epsilon 4 and epsilon 2 alleles suggest that these alleles are involved in the different mechanisms leading to increased BP in middle-aged and elderly subjects. Hypertension Research (2013) 36, 270-276; doi: 10.1038/hr.2012.175; published online 18 October 2012 (literal)
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