http://www.cnr.it/ontology/cnr/individuo/prodotto/ID285343

Regional mapping of myocardial hibernation phenotype in idiopathic end-stage dilated cardiomyopathy (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Regional mapping of myocardial hibernation phenotype in idiopathic end-stage dilated cardiomyopathy (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1111/jcmm.12198 (literal)

Alternative label

Lionetti, Vincenzo; Matteucci, Marco Luciano Sacha; Ribezzo, Marco; Di Silvestre, Dario; Brambilla, Francesca; Agostini, Silvia; Mauri, Pierluigi; Padeletti, Luigi; Pingitore, Alessandro; Delsedime, Luisa; Rinaldi, Mauro M D; Recchia, Fabio Anastasio; Pucci, Angela A. (2014)
Regional mapping of myocardial hibernation phenotype in idiopathic end-stage dilated cardiomyopathy
in Journal of Cellular and Molecular Medicine (Print)
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Lionetti, Vincenzo; Matteucci, Marco Luciano Sacha; Ribezzo, Marco; Di Silvestre, Dario; Brambilla, Francesca; Agostini, Silvia; Mauri, Pierluigi; Padeletti, Luigi; Pingitore, Alessandro; Delsedime, Luisa; Rinaldi, Mauro M D; Recchia, Fabio Anastasio; Pucci, Angela A. (literal)

Pagina inizio

396 (literal)

Pagina fine

414 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/record/display.url?eid=2-s2.0-84894551930&origin=inward (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

18 (literal)

Rivista

Journal of Cellular and Molecular Medicine (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

3 (literal)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Scuola Superiore Sant'Anna di Studi Universitari e di Perfezionamento; Consiglio Nazionale delle Ricerche; Azienda Sanitaria Ospedaliera Molinette San Giovanni Battista Di Torino; Institute for Biomedical Technologies, Segrate; Universita degli Studi di Firenze; Istituto di Fisiologia Clinica del CNR; Temple University School of Medicine; Azienda Ospedaliera-Universitaria Pisana (literal)

Titolo

Regional mapping of myocardial hibernation phenotype in idiopathic end-stage dilated cardiomyopathy (literal)

Abstract

Myocardial hibernation (MH) is a well-known feature of human ischaemic cardiomyopathy (ICM), whereas its presence in human idiopathic dilated cardiomyopathy (DCM) is still controversial. We investigated the histological and molecular features of MH in left ventricle (LV) regions of failing DCM or ICM hearts. We examined failing hearts from DCM (n = 11; 41.9 ± 5.45 years; left ventricle-ejection fraction (LV-EF), 18 ± 3.16%) and ICM patients (n = 12; 58.08 ± 1.7 years; LVEF, 21.5 ± 6.08%) undergoing cardiac transplantation, and normal donor hearts (N, n = 8). LV inter-ventricular septum (IVS) and antero-lateral free wall (FW) were transmurally (i.e. sub-epicardial, mesocardial and sub-endocardial layers) analysed. LV glycogen content was shown to be increased in both DCM and ICM as compared with N hearts (P < 0.001), with a U-shaped transmural distribution (lower values in mesocardium). Capillary density was homogenously reduced in both DCM and ICM as compared with N (P < 0.05 versus N), with a lower decrease independent of the extent of fibrosis in sub-endocardial and sub-epicardial layers of DCM as compared with ICM. HIF1-? and nestin, recognized ischaemic molecular hallmarks, were similarly expressed in DCM-LV and ICM-LV myocardium. The proteomic profile was overlapping by ~50% in DCM and ICM groups. Morphological and molecular features of MH were detected in end-stage ICM as well as in end-stage DCM LV, despite epicardial coronary artery patency and lower fibrosis in DCM hearts. Unravelling the presence of MH in the absence of coronary stenosis may be helpful to design a novel approach in the clinical management of DCM. © 2014 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. (literal)

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