Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1007/s00125-014-3219-7 (literal)

Alternative label

• Tura A.; Muscelli E.; Gastaldelli A.; Ferrannini E.; Mari A. (2014)
  Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic
  in Diabetologia (Berl.)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Tura A.; Muscelli E.; Gastaldelli A.; Ferrannini E.; Mari A. (literal)

Pagina inizio

• 1199 (literal)

Pagina fine

• 1203 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

• http://www.ncbi.nlm.nih.gov/pubmed/24658843 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 57 (literal)

Rivista

• Diabetologia (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Institute of Biomedical Engineering, National Research Council, Corso Stati Uniti, 4, 35127 Padova, Italy; Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy; Institute of Clinical Physiology, National Research Council, Pisa, Italy (literal)

Titolo

• Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic (literal)

Abstract

• AIMS/HYPOTHESIS: Oral glucose elicits a higher insulin secretory response than intravenous glucose at matched glucose concentrations. This potentiation, known as the incretin effect, is typically expressed as the difference between the total insulin response to oral vs intravenous glucose. This approach does not describe the dynamics of insulin secretion potentiation. We developed a model for the simultaneous analysis of oral and isoglycaemic intravenous glucose responses to dissect the impact of hyperglycaemia and incretin effect on insulin secretion and beta cell function. METHODS: Fifty individuals (23 with normal glucose tolerance [NGT], 17 with impaired glucose tolerance [IGT] and ten with type 2 diabetes) received an OGTT and an isoglycaemic test with measurement of plasma glucose, insulin, C-peptide, glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). Our model featured an incretin potentiation factor (PINCR) for the dose-response function relating insulin secretion to glucose concentration, and an effect on early secretion (rate sensitivity). RESULTS: In NGT, PINCR rapidly increased and remained sustained during the whole OGTT (mean PINCR>1, p<0.009). The increase was transient in IGT and virtually absent in diabetes. Mean PINCR was significantly but loosely correlated with GLP-1 AUC (r=0.49, p<0.006), while the relationship was not significant for GIP. An incretin effect on rate sensitivity was present in all groups (p<0.002). CONCLUSIONS/INTERPRETATION: The onset of the incretin effect is rapid and sustained in NGT, transient in IGT and virtually absent in diabetes. The profiles of the incretin effect are poorly related to those of the incretin hormones. (literal)

Prodotto di

• Istituto di neuroscienze (IN) (Istituto)
• Institute of biomedical engineering (ISIB) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)
• Istituto di fisiologia clinica (IFC) (Istituto)

Autore CNR

• ANDREA MARI (Unità di personale interno)
• eleuterio ferrannini (Unità di personale esterno)
• AMALIA GASTALDELLI (Persona)
• ANDREA TURA (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic" (Insieme di parole chiave)

Incoming links:

Prodotto

• Institute of biomedical engineering (ISIB) (Istituto)
• Istituto di neuroscienze (IN) (Istituto)
• Istituto di fisiologia clinica (IFC) (Istituto)
• Metodi e modelli matematici per la ricerca clinica sul metabolismo, il diabete e sue complicanze (ME.P06.016.001) (Modulo)

Autore CNR di

• AMALIA GASTALDELLI (Persona)
• ANDREA MARI (Unità di personale interno)
• ANDREA TURA (Unità di personale interno)
• eleuterio ferrannini (Unità di personale esterno)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Diabetologia (Rivista)

Insieme di parole chiave di

• Keywords of "Altered pattern of the incretin effect as assessed by modelling in individuals with glucose tolerance ranging from normal to diabetic" (Insieme di parole chiave)