Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1371/journal.pone.0078036 (literal)

Alternative label

• Campolongo, Patrizia; Ratano, Patrizia; Ciotti, Maria Teresa; Florenzano, Fulvio; Nori, Stefania Lucia; Marolda, Roberta; Palmery, Maura; Rinaldi, Anna Maria; Zona, Cristina; Possenti, Roberta; Calissano, Pietro; Severini, Cinzia (2013)
  Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels
  in PloS one
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Campolongo, Patrizia; Ratano, Patrizia; Ciotti, Maria Teresa; Florenzano, Fulvio; Nori, Stefania Lucia; Marolda, Roberta; Palmery, Maura; Rinaldi, Anna Maria; Zona, Cristina; Possenti, Roberta; Calissano, Pietro; Severini, Cinzia (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 8 (literal)

Rivista

• PloS one (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 11 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 11 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• Sapienza University Rome; Consiglio Nazionale delle Ricerche (CNR); European Brain Res Inst; Univ Salerno Med Campus; University of Rome Tor Vergata; IRCCS Fdn Santa Lucia (literal)

Titolo

• Systemic Administration of Substance P Recovers Beta Amyloid-Induced Cognitive Deficits in Rat: Involvement of Kv Potassium Channels (literal)

Abstract

• Reduced levels of Substance P (SP), an endogenous neuropeptide endowed with neuroprotective and anti-apoptotic properties, have been found in brain and spinal fluid of Alzheimer's disease (AD) patients. Potassium (K+) channel dysfunction is implicated in AD development and the amyloid-beta (A beta)-induced up-regulation of voltage-gated potassium channel subunits could be considered a significant step in A beta brain toxicity. The aim of this study was to evaluate whether SP could reduce, in vivo, A beta-induced overexpression of Kv subunits. Rats were intracerebroventricularly infused with amyloid-beta 25-35 (A beta(25-35), 20 mu g) peptide. SP (50 mu g/Kg, i.p.) was daily administered, for 7 days starting from the day of the surgery. Here we demonstrate that the A beta infused rats showed impairment in cognitive performances in the Morris water maze task 4 weeks after A beta(25-35) infusion and that this impairing effect was prevented by SP administration. Kv1.4, Kv2.1 and Kv4.2 subunit levels were quantified in hippocampus and in cerebral cortex by Western blot analysis and immunofluorescence. Interestingly, SP reduced Kv1.4 levels overexpressed by A beta, both in hippocampus and cerebral cortex. Our findings provide in vivo evidence for a neuroprotective activity of systemic administration of SP in a rat model of AD and suggest a possible mechanism underlying this effect. (literal)

Prodotto di

• Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (Modulo)

Autore CNR

• CINZIA SEVERINI (Persona)

Incoming links:

Autore CNR di

• CINZIA SEVERINI (Persona)

Prodotto

• Patologie del S.N. e Fattori di Crescita (ME.P02.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• PloS one (Rivista)