http://www.cnr.it/ontology/cnr/individuo/prodotto/ID284900
Predictive factors of hyperlipidemia in HIV-infected subjects receiving lopinavir/ritonavir (Articolo in rivista)
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- Label
- Predictive factors of hyperlipidemia in HIV-infected subjects receiving lopinavir/ritonavir (Articolo in rivista) (literal)
- Anno
- 2006-01-01T00:00:00+01:00 (literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
- 10.1089/aid.2006.22.132 (literal)
- Alternative label
Bongiovanni, M; Bini, T; Cicconi, P; Landonio, S; Meraviglia, P; Testa, L; Di Biagio, A; Chiesa, E; Tordato, F; Biasi, P; Adorni, F; Monforte, AD (2006)
Predictive factors of hyperlipidemia in HIV-infected subjects receiving lopinavir/ritonavir
in AIDS research and human retroviruses
(literal)
- Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
- Bongiovanni, M; Bini, T; Cicconi, P; Landonio, S; Meraviglia, P; Testa, L; Di Biagio, A; Chiesa, E; Tordato, F; Biasi, P; Adorni, F; Monforte, AD (literal)
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- ISI Web of Science (WOS) (literal)
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- University of Milan; L Sacco; L Sacco; Busto Arsizio Hosp; University of Genoa; Consiglio Nazionale delle Ricerche (CNR) (literal)
- Titolo
- Predictive factors of hyperlipidemia in HIV-infected subjects receiving lopinavir/ritonavir (literal)
- Abstract
- We studied 382 multiexperienced HIV-infected patients followed up for >= 3 months after starting lopinavir/ri-tonavir (LPV/r) to identify the factors predicting hypertriglyceridemia and high non-HDL cholesterol levels (triglycerides >= 200 mg/dl and/or non-HDL cholesterol >= 190 mg/dl) after 6 and 12 months of LPV/r exposure. The predictors of hypertriglyceridemia were higher baseline triglyceride levels [OR: 2.28 (95% CI: 1.67-3.12) for each additional 100 mg/dl; p = 0.001], the total duration of antiretroviral treatment [OR: 1.26 (95% CI: 1.12-1.41) for each additional year; p = 0.01], CDC stage C (OR: 2.06; 95% CI: 1.24-3.88; p = 0.02), and male gender (OR: 2.52; 95% CI: 1.42-4.74; p = 0.02); intravenous drug abusers seem less likely to develop the event (OR: 0.52; 95% CI: 0.37-0.92; p = 0.03). The predictors of high non- HDL cholesterol levels were higher baseline levels [OR: 3.92 (95% CI: 1.92-6.24) for each additional 100 mg/dl; p = 0.001) and the combination of NRTIs and NNRTIs with LPV/r (OR: 1.83; 95% CI: 1.10-3.69; p = 0.03). The 75 patients stopping LPV/r showed a significant reduction in median triglyceride and non-HDL cholesterol levels after 3 months of 39 mg/dl and 20 mg/dl (p = 0.01 for both), respectively. Patients with high triglyceride and non-HDL cholesterol levels at the start of LPV/r treatment are at higher risk of developing hyperlipidemia. (literal)
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