http://www.cnr.it/ontology/cnr/individuo/prodotto/ID284764

Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00213-014-3641-z (literal)

Alternative label

Serra V.; Fattore L.; Scherma M.; Collu R.; Spano M.S.; Fratta W.; Fadda P. (2014)
Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat
in Psychopharmacologia
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Serra V.; Fattore L.; Scherma M.; Collu R.; Spano M.S.; Fratta W.; Fadda P. (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/inward/record.url?eid=2-s2.0-84902023102&partnerID=q2rCbXpz (literal)

Rivista

Psychopharmacologia (Rivista)

Note

Scopu (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Department of Biomedical Sciences, Division of Neuroscience and Clinical Pharmacology, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, CA 09042, Italy; Center of Excellence 'Neurobiology of Addiction', University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, CA 09042, Italy; CNR Institute of Neuroscience-Cagliari, National Research Council-Italy, University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato, CA 09042, Italy; National Institute of Neuroscience (INN), University of Cagliari, Cittadella Universitaria di Monserrato, Monserrato (CA), 09042, Italy; Institute of Translational Pharmacology, UOS of Cagliari, National Research Council, Scientific and Technological Park of Sardinia - Polaris, Pula, Italy (literal)

Titolo

Behavioural and neurochemical assessment of salvinorin A abuse potential in the rat (literal)

Abstract

Rationale Salvinorin A is a recreational drug derived from Salvia divinorum, a sage species long used as an entheogen. While salvinorin A has potent hallucinogenic properties, its abuse potential has not been assessed consistently in controlled behavioural and neurochemical studies in rodents. Objective This study aimed to assess salvinorin A abuse potential by measuring its capacity to establish and maintain self-administration behaviour and to modify dopamine (DA) levels in the nucleus accumbens (NAcc) of rats. Results Male Lister Hooded (LH) and Sprague-Dawley (SD) rats were allowed to self-administer salvinorin A (0.5 or 1.0 ?g/kg/infusion) intravenously 2 h/day for 20 days under a continuous schedule of reinforcement and lever pressing as operandum. LH rats discriminated between the active and inactive levers but did not reach the acquisition criterion for stable self-administration (>=12 active responses vs <=5 inactive responses for at least 5 consecutive days). SD rats discriminated between the two levers at the lower dose only but, like LH rats, never acquired stable self-administration behaviour. Systemic salvinorin A increased extracellular DA in the NAcc shell of both LH (at >=40 ?g/kg) and SD rats (at >=5 ?g/kg), but injection into the ventral tegmental area (VTA) induced no significant change in NAcc DA concentration in LH rats and only brief elevations in SD rats. Conclusions Salvinorin A differs from other commonly abused compounds since although it affects accumbal dopamine transmission, yet it is unable, at least at the tested doses, to sustain stable intravenous self-administration behaviour. © 2014 Springer-Verlag Berlin Heidelberg. (literal)

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