http://www.cnr.it/ontology/cnr/individuo/prodotto/ID284759

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies (Articolo in rivista)

Type

Prodotto della ricerca (Classe)
Articolo in rivista (Classe)

Label

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies (Articolo in rivista) (literal)

Anno

2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

10.1007/s00213-014-3564-8 (literal)

Alternative label

Porcu P.; Morrow A.L. (2014)
Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies
in Psychopharmacologia
(literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

Porcu P.; Morrow A.L. (literal)

Pagina inizio

3257 (literal)

Pagina fine

3272 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#url

http://www.scopus.com/inward/record.url?eid=2-s2.0-84901734410&partnerID=q2rCbXpz (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

231 (literal)

Rivista

Psychopharmacologia (Rivista)

Note

Scopu (literal)
PubMe (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

Neuroscience Institute, National Research Council of Italy (CNR), Cittadella Universitaria, Monserrato, Cagliari 09042, Italy; Departments of Psychiatry and Pharmacology, Bowles Center for Alcohol Studies, University of North Carolina School of Medicine, Chapel Hill, NC, United States (literal)

Titolo

Divergent neuroactive steroid responses to stress and ethanol in rat and mouse strains: relevance for human studies (literal)

Abstract

Rationale: Neuroactive steroids are endogenous or synthetic steroids that rapidly alter neuronal excitability via membrane receptors, primarily GABAA receptors. Neuroactive steroids regulate many physiological processes including hypothalamic-pituitary-adrenal (HPA) axis function, ovarian cycle, pregnancy, aging, and reward. Moreover, alterations in neuroactive steroid synthesis are implicated in several neuropsychiatric disorders. Objectives: This review will summarize the pharmacological properties and physiological regulation of neuroactive steroids, with a particular focus on divergent neuroactive steroid responses to stress and ethanol in rats, mice and humans. Results: GABAergic neuroactive steroids exert a homeostatic regulation of the HPA axis in rats and humans, whereby the increase in neuroactive steroid levels following acute stress counteracts HPA axis hyperactivity and restores homeostasis. In contrast, in C57BL/6J mice, acute stress decreases neurosteroidogenesis and neuroactive steroids exert paradoxical excitatory effects upon the HPA axis. Rats, mice and humans also differ in the neuroactive steroid responses to ethanol. Genetic variation in neurosteroidogenesis may explain the different neuroactive steroid responses to stress or ethanol. Conclusions: Rats and mouse strains show divergent effects of stress and ethanol on neuroactive steroids in both plasma and brain. The study of genetic variation in the various processes that determine neuroactive steroids levels as well as their effects on cell signaling may underlie these differences and may play a relevant role for the potential therapeutic benefits of neuroactive steroids. (literal)

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