Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives (Articolo in rivista)

Type

• Prodotto della ricerca (Classe)
• Articolo in rivista (Classe)

Label

• Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives (Articolo in rivista) (literal)

Anno

• 1998-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1016/S0306-4522(97)00628-3 (literal)

Alternative label

• Melcangi, RC; Magnaghi, V; Cavarretta, I; Martini, L; Piva, F (1998)
  Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives
  in Neuroscience
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Melcangi, RC; Magnaghi, V; Cavarretta, I; Martini, L; Piva, F (literal)

Pagina inizio

• 569 (literal)

Pagina fine

• 578 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 85 (literal)

Rivista

• Neuroscience (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 10 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 2 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Milan (literal)

Titolo

• Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives (literal)

Abstract

• The data provide the first demonstration that ageing decreases the gene expression of two major components of the peripheral myelin in the sciatic nerve; they also show that this phenomenon may be partially reversed by progesterone derivatives, which might act by stimulating Po gene expression in the Schwann cells. (C) 1998 IBRO. Published by Elsevier Science Ltd. (literal)
• The data here reported show that the gene expression of the glycoprotein Po and of the myelin basic protein, the major components of myelin in the peripheral nervous system, dramatically decreases with ageing in the sciatic nerve of normal male rats. A one-month treatment with dihydroprogesterone, the Sa-reduced derivative of progesterone, is able to partially restore the fall in Po gene expression occuring in the sciatic nerve of aged male rats, without significantly modifying the gene expression of the myelin basic protein. In cultures of neonatal Schwann cells (the peripheral nervous system elements involved in the synthesis of myelin), the addition of progesterone and of dihydroprogesterone significantly increases Po gene expression; the 3 alpha-reduced metabolite of dihydroprogesterone, tetrahydroprogesterone proved to be even more effective. These data suggest that the effect of progesterone is linked to its conversion into dihydroprogesterone and especially into tetrahydroprogesterone, since Schwann cells possess the 5 alpha-reductase-3 alpha-hydroxysteroid dehydrogenase system. (literal)

Prodotto di

• Oncologia molecolare : differenziamento cellule epiteliali, caratterizzazione cellule staminali mammarie. (ME.P03.010.001) (Modulo)

Autore CNR

• ILEANA ZUCCHI (Persona)

Insieme di parole chiave

• Keywords of "Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• ILEANA ZUCCHI (Persona)

Prodotto

• Oncologia molecolare : differenziamento cellule epiteliali, caratterizzazione cellule staminali mammarie. (ME.P03.010.001) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Neuroscience (Rivista)

Insieme di parole chiave di

• Keywords of "Age-induced decrease of glycoprotein Po and myelin basic protein gene expression in the rat sciatic nerve. Repair by steroid derivatives" (Insieme di parole chiave)