Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA) (Articolo in rivista)

Type
Label
  • Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA) (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/1469-0691.12229 (literal)
Alternative label
  • Rusconi, S.; Adorni, F.; Bruzzone, B.; Di Biagio, A.; Meini, G.; Callegaro, A.; Punzi, G.; Boeri, E.; Pecorari, M.; Monno, L.; Gianotti, N.; Butini, L.; Galli, L.; Polilli, E.; Galli, M. (2013)
    Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA)
    in Clinical microbiology and infection (Print)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Rusconi, S.; Adorni, F.; Bruzzone, B.; Di Biagio, A.; Meini, G.; Callegaro, A.; Punzi, G.; Boeri, E.; Pecorari, M.; Monno, L.; Gianotti, N.; Butini, L.; Galli, L.; Polilli, E.; Galli, M. (literal)
Pagina inizio
  • E443 (literal)
Pagina fine
  • E446 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 19 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 4 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Milan; ITB CNR; University of Genoa; University of Siena; Osped Riuniti Bergamo; University of Bari; Vita-Salute San Raffaele University; Policlin Univ; University of Bari; Vita-Salute San Raffaele University; Marche Polytechnic University; Osped Pediat Meyer; Osped Santo Spirito (literal)
Titolo
  • Prevalence of etravirine (ETR)-RAMs at NNRTI failure and predictors of resistance to ETR in a large Italian resistance database (ARCA) (literal)
Abstract
  • The prevalence of drug resistance associated with the failure of non-nucleoside reverse transcriptase inhibitor (NNRTI)-based regimens and the predictors of resistance to Etravirine (ETR) were assessed in 2854 subjects: 39<18 (paediatric) and 281518 (adult) years old. These subjects failed to respond to their current NNRTI treatment, were three-class experienced and had been exposed to NNRTI for 3months. A total of 1827 adult (64.9%) and 32 paediatric subjects (82.1%) harboured the virus with at least one ETR mutation. V179I, Y181C and G190A were the most frequent mutations in both groups. A significantly increased risk of ETR resistance with all three algorithms (Monogram (MGR) >3, Tibotec (TBT) >2 and enhanced MGR (ENH) 4) emerged in the paediatric population. Multivariate analysis revealed an increased risk of developing TBT >2 for NNRTI exposure, ENH 4 for NNRTI and EFV exposure in paediatric subjects; NVP exposure and higher (3.5 log10) HIV-RNA values for all three algorithms in adult subjects, whereas CD4200/L appeared to be protective. The risk of being ETR resistant was more than doubled for paediatric vs. adult subjects, probably due to a more extensive use of NNRTI and an incomplete virological control. (literal)
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