MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration (Articolo in rivista)

Type
Label
  • MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1038/ncomms4633 (literal)
Alternative label
  • Cebrian C.; Zucca F.A.; Mauri P.; Steinbeck J.A.; Studer L.; Scherzer C.R.; Kanter E.; Budhu S.; Mandelbaum J.; Vonsattel J.P.; Zecca L.; Loike J.D.; Sulzer D. (2014)
    MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration
    in Nature communications
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cebrian C.; Zucca F.A.; Mauri P.; Steinbeck J.A.; Studer L.; Scherzer C.R.; Kanter E.; Budhu S.; Mandelbaum J.; Vonsattel J.P.; Zecca L.; Loike J.D.; Sulzer D. (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 5 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 14 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Carolina Cebrian, Ellen Kanter and David Sulzer (Department of Neurology, Columbia University Medical Center, New York, New York 10032, USA); Fabio Andrea Zucca; Pierluigi Mauri and Luigi Zecca (Institute of Biomedical Technologies, National Research Council of Italy, Segrate, Milano 20090, Italy); Julius A. Steinbeck and Lorenz Studer (Center for Stem Cell Biology, Sloan-Kettering Institute, New York, New York 10065, USA); Clemens R. Scherzer (The Neurogenomics Laboratory, Harvard Medical School and Brigham and Women's Hospital, Cambridge, Massachusetts 02139, USA); Sadna Budhu (Sloan Kettering Memorial Hospital, New York, New York, USA); Jonathan Mandelbaum (Discovery Oncology Biology, Takeda Pharmaceuticals International Co., 40 Landsdowne Street, Cambridge, MA 021369, USA); Jean P. Vonsattel (New York Brain Bank, Columbia University Medical Center, New York, New York 10032, USA); John D. Loike (Department of Physiology and Cellular Biophysics, Columbia University Medical Center, New York, New York 10032, USA). (literal)
Titolo
  • MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration (literal)
Abstract
  • Subsets of rodent neurons are reported to express major histocompatibility complex class I (MHC-I), but such expression has not been reported in normal adult human neurons. Here we provide evidence from immunolabel, RNA expression and mass spectrometry analysis of postmortem samples that human catecholaminergic substantia nigra and locus coeruleus neurons express MHC-I, and that this molecule is inducible in human stem cell-derived dopamine (DA) neurons. Catecholamine murine cultured neurons are more responsive to induction of MHC-I by gamma-interferon than other neuronal populations. Neuronal MHC-I is also induced by factors released from microglia activated by neuromelanin or alpha-synuclein, or high cytosolic DA and/or oxidative stress. DA neurons internalize foreign ovalbumin and display antigen derived from this protein by MHC-I, which triggers DA neuronal death in the presence of appropriate cytotoxic T cells. Thus, neuronal MHC-I can trigger antigenic response, and catecholamine neurons may be particularly susceptible to T-cell-mediated cytotoxic attack. (literal)
Prodotto di
Autore CNR

Incoming links:


Autore CNR di
Prodotto
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi
data.CNR.it