The dopamine beta-hydroxylase inhibitor, nepicastat, reduces different alcohol-related behaviors in rats (Articolo in rivista)

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  • The dopamine beta-hydroxylase inhibitor, nepicastat, reduces different alcohol-related behaviors in rats (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/acer.12520 (literal)
Alternative label
  • Colombo G, Maccioni P, Vargiolu D, Loi B, Lobina C, Zaru A, Carai MAM, Gessa GL (2014)
    The dopamine beta-hydroxylase inhibitor, nepicastat, reduces different alcohol-related behaviors in rats
    in Alcoholism, clinical and experimental research
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Colombo G, Maccioni P, Vargiolu D, Loi B, Lobina C, Zaru A, Carai MAM, Gessa GL (literal)
Pagina inizio
  • 2345 (literal)
Pagina fine
  • 2353 (literal)
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  • 38 (literal)
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  • 9 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 9 (literal)
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  • Neuroscience Institute, National Research Council of Italy, Section of Cagliari, Monserrato (CA), Italy (literal)
Titolo
  • The dopamine beta-hydroxylase inhibitor, nepicastat, reduces different alcohol-related behaviors in rats (literal)
Abstract
  • Background: Recent experimental data indicate that treatment with the selective dopamine ?-hydroxylase inhibitor, nepicastat, suppressed different reward-related behaviors, including self-administration of chocolate and reinstatement of cocaine- and chocolate-seeking, in rats. The present study was designed to extend to different alcohol-related behaviors the investigation on the \"anti-addictive\" properties of nepicastat. Methods and Results: Sardinian alcohol-preferring (sP) rats, selectively bred for excessive alcohol consumption, were used. Repeated treatment with nepicastat (0, 25, 50, and 100 mg/kg, i.p., once daily for 10 consecutive days) produced a stable and dose-related reduction in daily alcohol intake in sP rats exposed to the homecage 2-bottle \"alcohol (10% v/v) vs water\" choice regimen with unlimited access. Acute treatment with nepicastat (0, 25, 50, and 100 mg/kg, i.p.) completely suppressed the \"alcohol deprivation effect\" (i.e., the temporary increase in alcohol intake occurring after a period of abstinence; model of alcohol relapse episodes) in sP rats exposed to the 2-bottle choice regimen. Acute treatment with nepicastat (0, 25, 50, and 100 mg/kg, i.p.) dose-dependently and selectively reduced oral alcohol self-administration in sP rats trained to lever-respond for alcohol (15% v/v) on a FR4 schedule of reinforcement. Finally, combination of nepicastat (0, 50, and 100 mg/kg, i.p.) and alcohol (2 g/kg, i.g.) did not alter spontaneous locomotor activity in sP rats. Conclusions: Together, these data extend to alcohol the capacity of nepicastat to suppress different behaviors motivated by natural stimuli and drugs of abuse. (literal)
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