http://www.cnr.it/ontology/cnr/individuo/prodotto/ID284430

Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials (Articolo in rivista)

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Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials (Articolo in rivista) (literal)

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Alternative label

Silva A. K. A. [ 1,2 ] ; Di Corato R. [ 1,2 ] ; Pellegrino T. [ 3,4 ] ; Chat S. [ 5 ] ; Pugliese G. [ 3 ] ; Luciani N. [ 1,2 ] ; Gazeau F. [ 1,2 ] ; Wilhelm C. [ 1,2 ] (2013)
Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials
in Nanoscale (Print)
(literal)

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Silva A. K. A. [ 1,2 ] ; Di Corato R. [ 1,2 ] ; Pellegrino T. [ 3,4 ] ; Chat S. [ 5 ] ; Pugliese G. [ 3 ] ; Luciani N. [ 1,2 ] ; Gazeau F. [ 1,2 ] ; Wilhelm C. [ 1,2 ] (literal)

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[ 1 ] CNRS, UMR 7057, Lab Matiere & Syst Complexes, F-75205 Paris 13, France [ 2 ] Univ Paris Diderot, F-75205 Paris 13, France [ 3 ] Inst Italiano Tecnol, I-16163 Genoa, Italy [ 4 ] CNR, Nanosci Inst, NNL, I-73100 Lecce, Italy [ 5 ] INRA, MIMA2 UR1196, F-78352 Jouy En Josas, France (literal)

Titolo

Cell-derived vesicles as a bioplatform for the encapsulation of theranostic nanomaterials (literal)

Abstract

There is a great deal of interest in the development of nanoplatforms gathering versatility and multifunctionality. The strategy reported herein meets these requirements and further integrates a cell-friendly shell in a bio-inspired approach. By taking advantage of a cell mechanism of biomolecule transport using vesicles, we engineered a hybrid biogenic nanoplatform able to encapsulate a set of nanoparticles regardless of their chemistry or shape. As a proof of versatility, different types of hybrid nanovesicles were produced: magnetic, magnetic-metallic and magnetic-fluorescent vesicles, either a single component or multiple components, combining the advantageous properties of each integrant nanoparticle. These nanoparticle-loaded vesicles can be manipulated, monitored by MRI and/or fluorescence imaging methods, while acting as efficient nano-heaters. The resulting assets for targeting, imaging and therapy converge for the outline of a new generation of nanosystems merging versatility and multifunctionality into a bio-camouflaged and bio-inspired approach. (literal)

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