Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles (Articolo in rivista) (literal)

Anno

• 2013-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1021/nl400188q (literal)

Alternative label

• Riedinger A. [ 1 ] ; Guardia P. [ 1 ] ; Curcio A. [ 1 ] ; Garcia M. A. [ 2,3 ] ; Cingolani R. [ 1 ] ; Manna L. [ 1 ] ; Pellegrino T. [ 1,4 ] (2013)
  Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles
  in Nano letters (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Riedinger A. [ 1 ] ; Guardia P. [ 1 ] ; Curcio A. [ 1 ] ; Garcia M. A. [ 2,3 ] ; Cingolani R. [ 1 ] ; Manna L. [ 1 ] ; Pellegrino T. [ 1,4 ] (literal)

Pagina inizio

• 2399 (literal)

Pagina fine

• 2406 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 13 (literal)

Rivista

• Nano letters (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 8 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 6 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• [ 1 ] Ist Italiano Tecnol, I-16163 Genoa, Italy [ 2 ] CSIC, Inst Ceram & Vidrio, E-28049 Madrid, Spain [ 3 ] IMDEA Nanociencia, E-28049 Madrid, Spain [ 4 ] Natl Nanotechnol Lab CNR NANO, I-73100 Lecce, Italy (literal)

Titolo

• Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles (literal)

Abstract

• Local heating can be produced by iron oxide nanoparticles (IONPs) when exposed to an alternating magnetic field (AMF). To measure the temperature profile at the nanoparticle surface with a subnanometer resolution, here we present a molecular temperature probe based on the thermal decomposition of a thermo-sensitive molecule, namely, azobis[N-(2-carboxyethyl)-2-methylpropionamidine]. Fluoresceineamine (FA) was bound to the azo molecule at the IONP surface functionalized with poly(ethylene glycol) (PEG) spacers of different molecular weights. Significant local heating, with a temperature increase up to 45 degrees C, was found at distances below 0.5 nm from the surface of the nanoparticle, which decays exponentially with increasing distance. Furthermore, the temperature increase was found to scale linearly with the applied field at all distances. We implemented these findings in an AMF-triggered drug release system in which doxorubicin was covalently linked at different distances from the IONP surface bearing the same thermo-labile azo molecule. We demonstrated the AMF triggered distance-dependent release of the drug in a cytotoxicity assay on KB cancer cells. (literal)

Prodotto di

• Celle solari organiche e ibride (MD.P06.007.002) (Modulo)

Autore CNR

• TERESA PELLEGRINO (Unità di personale interno)

Insieme di parole chiave

• Keywords of "Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles" (Insieme di parole chiave)

Incoming links:

Autore CNR di

• TERESA PELLEGRINO (Unità di personale interno)

Prodotto

• Celle solari organiche e ibride (MD.P06.007.002) (Modulo)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Nano letters (Rivista)

Insieme di parole chiave di

• Keywords of "Subnanometer Local Temperature Probing and Remotely Controlled Drug Release Based on Azo-Functionalized Iron Oxide Nanoparticles" (Insieme di parole chiave)