Testing A beta toxicity on primary CNS cultures using drug-screening microfluidic chips (Articolo in rivista)

Type

• Articolo in rivista (Classe)
• Prodotto della ricerca (Classe)

Label

• Testing A beta toxicity on primary CNS cultures using drug-screening microfluidic chips (Articolo in rivista) (literal)

Anno

• 2014-01-01T00:00:00+01:00 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi

• 10.1039/c4lc00174e (literal)

Alternative label

• Ruiz, A.; Joshi, P.; Mastrangelo, R.; Francolini, M.; Verderio, C.; Matteoli, M. (2014)
  Testing A beta toxicity on primary CNS cultures using drug-screening microfluidic chips
  in Lab on a chip (Print)
  (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori

• Ruiz, A.; Joshi, P.; Mastrangelo, R.; Francolini, M.; Verderio, C.; Matteoli, M. (literal)

Pagina inizio

• 2860 (literal)

Pagina fine

• 2866 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume

• 14 (literal)

Rivista

• Lab on a chip (Rivista)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali

• 7 (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo

• 15 (literal)

Note

• ISI Web of Science (WOS) (literal)

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni

• University of Milan; Fdn Filarete; University of Trieste; Consiglio Nazionale delle Ricerche (CNR); Humanitas Clin & Res Ctr (literal)

Titolo

• Testing A beta toxicity on primary CNS cultures using drug-screening microfluidic chips (literal)

Abstract

• Open microscale cultures of primary central nervous system (CNS) cells have been implemented in microfluidic chips that can expose the cells to physiological fluidic shear stress conditions. Cells in the chips were exposed to differently aggregated forms of beta-amyloid (A beta), i.e. conditions mimicking an Alzheimer's Disease environment, and treated with CNS drugs in order to assess the contribution of glial cells during pharmacological treatments. FTY720, a drug approved for the treatment of Multiple Sclerosis, was found to play a marked neuroprotective role in neuronal cultures as well as in microglia-enriched neuronal cultures, preventing neurodegeneration after cell exposure to neurotoxic oligomers of A beta. (literal)

Prodotto di

• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)
• Istituto di neuroscienze (IN) (Istituto)

Autore CNR

• MICHELA MATTEOLI (Persona)
• CLAUDIA VERDERIO (Unità di personale interno)
• MAURA FRANCOLINI (Persona)

Incoming links:

Prodotto

• Istituto di neuroscienze (IN) (Istituto)
• Farmacologia Cellulare e Molecolare delle Cellule Nervose (ME.P02.007.001) (Modulo)

Autore CNR di

• CLAUDIA VERDERIO (Unità di personale interno)
• MICHELA MATTEOLI (Persona)
• MAURA FRANCOLINI (Persona)
• http://www.cnr.it/ontology/cnr/individuo/unitaDiPersonaleEsterno/ID24555

Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#rivistaDi

• Lab on a chip (Rivista)