Human cord blood gamma delta T cells expressing public V gamma 2 chains dominate the response to bisphosphonate plus interleukin-15 (Articolo in rivista)

Type
Label
  • Human cord blood gamma delta T cells expressing public V gamma 2 chains dominate the response to bisphosphonate plus interleukin-15 (Articolo in rivista) (literal)
Anno
  • 2013-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1111/imm.12039 (literal)
Alternative label
  • Cairo C.; Sagnia B.; Cappelli G.; Colizzi V.; Leke R.G.F.; Leke R.J.; Pauza C.D. (2013)
    Human cord blood gamma delta T cells expressing public V gamma 2 chains dominate the response to bisphosphonate plus interleukin-15
    in Immunology (Oxf., Online)
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cairo C.; Sagnia B.; Cappelli G.; Colizzi V.; Leke R.G.F.; Leke R.J.; Pauza C.D. (literal)
Pagina inizio
  • 346 (literal)
Pagina fine
  • 360 (literal)
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  • http://www.scopus.com/inward/record.url?eid=2-s2.0-84874971805&partnerID=q2rCbXpz (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 138 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 4 (literal)
Note
  • Scopu (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • Institute of Human Virology, University of Maryland Baltimore, Baltimore, MD, United States (literal)
Titolo
  • Human cord blood gamma delta T cells expressing public V gamma 2 chains dominate the response to bisphosphonate plus interleukin-15 (literal)
Abstract
  • Summary: Compared with adults, the circulating V gamma 2V delta 2 T-cell population in cord blood is present at low levels and does not show the strong bias for V gamma 2-J gamma 1.2 rearrangements. These features may be a result of limited exposure to stimulatory phosphoantigens, lack of T-cell-derived interleukin-2 (IL-2) or both. In cord blood mononuclear cell cultures, a single round of stimulation, using aminobisphosphonates to elevate phosphoantigen levels, resulted in expansion of adult-like V gamma 2 chains and accumulation of memory cells with cytotoxic potential. Selection was similar using IL-2 or myeloid-derived IL-15. The V gamma 2V delta 2 T cells present in neonates are capable of generating potent immune responses even when relying on IL-15. (literal)
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