Cord Blood V gamma 2V delta 2 T Cells Provide a Molecular Marker for the Influence of Pregnancy-Associated Malaria on Neonatal Immunity (Articolo in rivista)

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  • Cord Blood V gamma 2V delta 2 T Cells Provide a Molecular Marker for the Influence of Pregnancy-Associated Malaria on Neonatal Immunity (Articolo in rivista) (literal)
Anno
  • 2014-01-01T00:00:00+01:00 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#doi
  • 10.1093/infdis/jit802 (literal)
Alternative label
  • Cairo C.; Longinaker N.; Cappelli G.; Leke R.G.; Ondo M.M.; Djokam R.; Fogako J.; Leke R.J.; Sagnia B.; Sosso S.; Colizzi V.; Pauza C.D. (2014)
    Cord Blood V gamma 2V delta 2 T Cells Provide a Molecular Marker for the Influence of Pregnancy-Associated Malaria on Neonatal Immunity
    in The Journal of infectious diseases
    (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#autori
  • Cairo C.; Longinaker N.; Cappelli G.; Leke R.G.; Ondo M.M.; Djokam R.; Fogako J.; Leke R.J.; Sagnia B.; Sosso S.; Colizzi V.; Pauza C.D. (literal)
Pagina inizio
  • 1653 (literal)
Pagina fine
  • 1662 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroVolume
  • 209 (literal)
Rivista
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#pagineTotali
  • 10 (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#numeroFascicolo
  • 10 (literal)
Note
  • ISI Web of Science (WOS) (literal)
Http://www.cnr.it/ontology/cnr/pubblicazioni.owl#affiliazioni
  • University of Maryland Baltimore; University System of Maryland; Chantal Biya Int Reference Ctr Res HIV AIDS Preve; University of Yaounde I; Cent Hosp; University of Rome Tor Vergata; University of Rome Tor Vergata (literal)
Titolo
  • Cord Blood V gamma 2V delta 2 T Cells Provide a Molecular Marker for the Influence of Pregnancy-Associated Malaria on Neonatal Immunity (literal)
Abstract
  • Background. Plasmodium falciparum placental infection primes the fetal immune system and alters infant immunity. Mechanisms leading to these outcomes are not completely understood. We focused on V gamma 2V delta 2 cells, which are part of the immune response against many pathogens, including P. falciparum. These unconventional lymphocytes respond directly to small, nonpeptidic antigens, independent of major histocompatibility complex presentation. We wondered whether placental malaria, which may increase fetal exposure to P. falciparum metabolites, triggers a response by neonatal V gamma 2V delta 2 lymphocytes that can be a marker for the extent of fetal exposure to malarial antigens. Methods. Cord blood mononuclear cells were collected from 15 neonates born to mothers with P. falciparum infection during pregnancy (8 with placental malaria) and 25 unexposed neonates. V gamma 2V delta 2cell phenotype, repertoire, and proliferative responses were compared between newborns exposed and those unexposed to P. falciparum. Results. Placental malaria-exposed neonates had increased proportions of central memory V gamma 2V delta 2 cells in cord blood, with an altered V?2 chain repertoire ex vivo and after stimulation. Conclusion. Our results suggest that placental malaria affects the phenotype and repertoire of neonatal V gamma 2V delta 2 lymphocytes. Placental malaria may lower the capacity for subsequent V gamma 2V delta 2 cell responses and impair the natural resistance to infectious diseases or the response to pediatric vaccination. (literal)
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